Please use this identifier to cite or link to this item: https://doi.org/10.1093/ije/dyac154
Title: Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study
Authors: Ong, Yi Ying 
Tint, Mya-Thway 
Aris, Izzuddin M 
Yuan, Wen Lun 
Chen, Ling-Wei 
Fortier, Marielle 
Choo, Jonathan 
Ling, Lieng Hsi 
Shek, Lynette 
Tan, Kok Hian 
Gluckman, Peter D 
Yap, Fabian 
Chong, Yap-Seng 
Godfrey, Keith M
Chong, Mary F-F 
Chan, Shiao-Yng
Eriksson, Johan G
Wlodek, Mary E 
Rolfe, Emanuella De Lucia
Ong, Ken K
Michael, Navin
Lee, Yung Seng 
Keywords: Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
Adiposity
fetal growth
birthweight
blood pressure
cardiovascular
AIR-DISPLACEMENT PLETHYSMOGRAPHY
FETAL-GROWTH RESTRICTION
BIRTH-WEIGHT
BLOOD-PRESSURE
ADIPOSE-TISSUE
DISEASE
HYPERTENSION
ORIGINS
INFANCY
OBESITY
Issue Date: 30-Jul-2022
Publisher: OXFORD UNIV PRESS
Citation: Ong, Yi Ying, Tint, Mya-Thway, Aris, Izzuddin M, Yuan, Wen Lun, Chen, Ling-Wei, Fortier, Marielle, Choo, Jonathan, Ling, Lieng Hsi, Shek, Lynette, Tan, Kok Hian, Gluckman, Peter D, Yap, Fabian, Chong, Yap-Seng, Godfrey, Keith M, Chong, Mary F-F, Chan, Shiao-Yng, Eriksson, Johan G, Wlodek, Mary E, Rolfe, Emanuella De Lucia, Ong, Ken K, Michael, Navin, Lee, Yung Seng (2022-07-30). Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. ScholarBank@NUS Repository. https://doi.org/10.1093/ije/dyac154
Abstract: BACKGROUND: Early epidemiological studies have associated low birthweight with increased cardiovascular risk. We aimed to examine whether the fat and fat-free components of birthweight have differing relationships with childhood cardiovascular risk markers. METHODS: In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort, air displacement plethysmography was conducted within 24 h after delivery in 290 naturally conceived singletons. We investigated associations of newborn cohort-specific standardized z-score of fat mass, fat-free mass, body fat percentage and birthweight on child (at 6 years of age) carotid intima-media thickness, pulse wave velocity, blood pressure, prehypertension/hypertension (>110/70 mmHg) and standardized systolic and diastolic blood pressure (SBP and DBP) trajectories (at 3-6 years of age), taking account of maternal education, height, tobacco exposure, parity, ethnicity, child's sex, gestational age, age at follow-up, and other maternal factors. RESULTS: Clear inverse associations were seen for blood pressure with z-score of fat mass [SBP, β (95% CI): -1.31 mmHg (-2.57, -0.06); DBP: -0.79 mmHg (-1.74, 0.15)] and body fat percentage [SBP: -1.46 mmHg (-2.73, -0.19); DBP: -0.80 mmHg (-1.75, 0.16)], but not with fat-free mass [SBP: 0.27 mmHg (-1.29, 1.83)]; DBP: -0.14 mmHg (-1.30, 1.03)]. Being in the lowest tertile of fat mass or body fat percentage was associated with higher blood pressure trajectories and prehypertension/hypertension risk [OR (95% CI), fat mass: 4.23 (1.41, 12.68); body fat percentage: 3.22 (1.09, 9.53)] without concomitantly higher overweight/obesity risk. CONCLUSIONS: At birth, low adiposity was associated with increased childhood blood pressure. Low newborn adiposity might serve as a marker of poor fetal growth or suboptimal intrauterine conditions associated with hypertension risk later in life.
Source Title: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/231161
ISSN: 03005771
14643685
DOI: 10.1093/ije/dyac154
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