Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/229382
Title: Comparison of Creatinine Based and Kidney Volume Based Methods of Estimating Glomerular Filtration Rates in Potential Living Kidney Donors Editorial Comment
Authors: Goh, Yen Seow Benjamin 
Wu, Mei Wen Fiona
Tai, Bee Choo 
Lee, King Chien Joe
Raman, Lata
Teo, Boon Wee 
Vathsala, Anatharaman 
Tiong, Ho Yee 
Keywords: Science & Technology
Life Sciences & Biomedicine
Urology & Nephrology
kidney
living donors
kidney function tests
creatinine
organ size
SERUM CREATININE
TRANSPLANTATION
OUTCOMES
GUIDELINES
DONATION
EQUATION
GFR
Issue Date: 1-Nov-2013
Publisher: ELSEVIER SCIENCE INC
Citation: Goh, Yen Seow Benjamin, Wu, Mei Wen Fiona, Tai, Bee Choo, Lee, King Chien Joe, Raman, Lata, Teo, Boon Wee, Vathsala, Anatharaman, Tiong, Ho Yee (2013-11-01). Comparison of Creatinine Based and Kidney Volume Based Methods of Estimating Glomerular Filtration Rates in Potential Living Kidney Donors Editorial Comment. JOURNAL OF UROLOGY 190 (5) : 1820-1826. ScholarBank@NUS Repository.
Abstract: Purpose: Accurate assessment of kidney function is critical to evaluate living kidney donors. Direct glomerular filtration rate measurement using isotopes is currently the gold standard but it is complex and costly. We evaluated the performance of surrogate markers of the glomerular filtration rate in living kidney donors by comparing direct measurement of the rate to the creatinine based equation estimated rate, the kidney volume based estimated rate using a newly developed equation and creatinine clearance. Materials and Methods: We first statistically compared direct glomerular filtration rate measurement to the results of the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) creatinine based equations, and to creatinine clearance in 54 potential renal donors from 2006 to 2010. In 32 donors with cross-sectional computerized tomography available we used measured functional renal volume with age, gender, weight and serum creatinine to estimate the rate based on kidney volume according to a previously reported model. Kidney volume based measurement was compared to direct glomerular filtration rate measurement and assessed against the results of the best performing creatinine based equation. Results: In the first group of 54 donors the correlation index of the estimated glomerular filtration rate according to MDRD and CKD-EPI creatinine based equations, and to creatinine clearance was low compared to direct measurement. In the subset of 32 potential donors the kidney volume based estimated rate correlated better with direct measurement than MDRD equation results with higher accuracy (estimated 87.5% and 75.0% within 30% and 10% of direct rate measurement, respectively). Conclusions: To estimate the glomerular filtration rate in healthy individuals a volume based model correlated better than the MDRD equation, which is the best performing creatinine based equation used to estimate the rate. By providing a more robust estimation of the glomerular filtration rate in healthy potential kidney donors, the volume based model adds value to routine preoperative computerized tomography above that of anatomical evaluation. © 2013 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.
Source Title: JOURNAL OF UROLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/229382
ISSN: 00225347
15273792
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