Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11136-015-0964-0
Title: Health-related quality of life of Asian patients with end-stage renal disease (ESRD) in Singapore
Authors: Yang, F
Griva, K 
Lau, T
Vathsala, A 
Lee, E
Ng, HJ
Mooppil, N
Foo, M
Newman, SP
Chia, KS
Luo, N 
Keywords: Science & Technology
Life Sciences & Biomedicine
Health Care Sciences & Services
Health Policy & Services
Public, Environmental & Occupational Health
Dialysis
End-stage renal disease
Health-related quality of life
PREFERENCE-BASED MEASURE
HEMODIALYSIS-PATIENTS
DIALYSIS PATIENTS
PERITONEAL-DIALYSIS
KIDNEY-DISEASE
PRACTICE PATTERNS
EQ-5D INDEX
OUTCOMES
SURVIVAL
SF-12
Issue Date: 1-Sep-2015
Publisher: SPRINGER
Citation: Yang, F, Griva, K, Lau, T, Vathsala, A, Lee, E, Ng, HJ, Mooppil, N, Foo, M, Newman, SP, Chia, KS, Luo, N (2015-09-01). Health-related quality of life of Asian patients with end-stage renal disease (ESRD) in Singapore. QUALITY OF LIFE RESEARCH 24 (9) : 2163-2171. ScholarBank@NUS Repository. https://doi.org/10.1007/s11136-015-0964-0
Abstract: Background: This study aimed to identify factors associated with the health-related quality of life (HRQOL) of multiethnic Asian end-stage renal disease (ESRD) patients treated with dialysis. The role of dialysis modality was also explored. Methods: Data used in this study were from two cross-sectional surveys of Singaporean ESRD patients on haemodialysis (HD) or peritoneal dialysis (PD). In both surveys, participants were assessed using the kidney disease quality of life (KDQOL) instrument and questions assessing socio-demographic characteristics. Clinical data including co-morbidity (measured by Charlson comorbidity index [CCI]), albumin level, haemoglobin level, and dialysis-related variables (e.g. dialysis vintage and dialysis adequacy) were retrieved from medical records. The 36-item KDQOL (KDQOL-36) was used to generate three summary scores (physical component summary [PCS], mental component summary [MCS] and kidney disease component summary [KDCS]) and two health utility scores (Short Form 6-dimension [SF-6D] and EuroQol 5-dimension [EQ-5D]). Linear regression analysis was performed to examine the association of factors with each of the HRQOL scale scores. Results: Five hundred and two patients were included in the study (mean age 57.1 years; male 52.4 %; HD 236, PD 266). Mean [standard deviation (SD)] PCS, MCS and KDCS scores were 37.9 (9.7), 46.4 (10.8) and 57.6 (18.1), respectively. Mean (SD) health utility score was 0.66 (0.12) for SF-6D and 0.60 (0.21) for EQ-5D. In multivariate regression analysis, factors found to be significantly associated with better HRQOL included: young (<45 years) or old age (>60 years), low CCI (<5), high albumin (≥37 g/l) and high haemoglobin (≥11 g/dl) with PCS; long dialysis vintage (≥3.5 years) with MCS; old age, Malay ethnicity and PD modality with KDCS; low CCI, high albumin and high haemoglobin with EQ-5D and high albumin with SF-6D. Conclusions: Clinical characteristics are better predictors of HRQOL in ESRD patients than socio-demographics in Singapore. Dialysis modality has no impact on the health utility of those patients.
Source Title: QUALITY OF LIFE RESEARCH
URI: https://scholarbank.nus.edu.sg/handle/10635/229292
ISSN: 09629343
15732649
DOI: 10.1007/s11136-015-0964-0
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