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Title: | Nephrectomy-induced reduced renal function and the health-related quality of life of living kidney donors | Authors: | Han, Xiao Lim, Joel Yu Ming Raman, Lata Tai, Bee Choo Kaur, Hersharan Goh, Angeline Ting Hui Vathsala, Anantharaman Tiong, Ho Yee |
Keywords: | Science & Technology Life Sciences & Biomedicine Surgery Transplantation chronic kidney disease kidney transplantation nephrectomy CORONARY-ARTERY CALCIFICATION DISEASE PROGRESSION MORTALITY RATES SF-36 RISK GFR |
Issue Date: | 1-Mar-2017 | Publisher: | WILEY | Citation: | Han, Xiao, Lim, Joel Yu Ming, Raman, Lata, Tai, Bee Choo, Kaur, Hersharan, Goh, Angeline Ting Hui, Vathsala, Anantharaman, Tiong, Ho Yee (2017-03-01). Nephrectomy-induced reduced renal function and the health-related quality of life of living kidney donors. CLINICAL TRANSPLANTATION 31 (3) : e12910. ScholarBank@NUS Repository. | Abstract: | Objective: To evaluate the health impact of nephrectomy on living kidney donors (LKDs) by comparing the health-related quality of life (HrQOL) scores measured by Short Form-36 (SF36) between those with and without postdonation renal function impairment (PRFI). Methods: Eighty-two LKDs (47 females, mean age=50.2±11.2 years) were prospectively recruited to participate in a SF-36 HrQOL survey. Chart review, individual baseline, and postoperative renal function (eGFR) was determined using the Modification of Diet in Renal Disease formula. PRFI was defined as eGFR<60 mL/min/1.73 m2 or proteinuria. Mean SF-36 domain scores were compared between those with and without PRFI. Results: After a median follow-up of 5.7 years, the prevalence of postdonation comorbidities was 29.3% (n=24) PRFI, 25.6% (n=21) hypertension, 6.1% (n=5) diabetes, and 3.7% (n=3) heart disease, and no LKDs developed end-stage renal disease. Mean eGFR before and after donor nephrectomy was 95.5±23.4 and 71.0±17.3 mL/min/1.73 m2 (P<.01). Mean SF-36 scores of LKDs were not significantly different between those with and without PRFI in all the domains (all P>.05). Similarly, the proportion of LKDs with PRFI did not differ significantly between the patients with SF-36 domain scores above and below the published reference values. Conclusion: Nephrectomy-induced PRFI may not have a significant impact on the HrQOL of the LKD population with a low proportion of other major comorbidities such as diabetes and ischemic heart disease. | Source Title: | CLINICAL TRANSPLANTATION | URI: | https://scholarbank.nus.edu.sg/handle/10635/229237 | ISSN: | 09020063 13990012 |
Appears in Collections: | Staff Publications Elements |
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