Please use this identifier to cite or link to this item: https://doi.org/10.1099/jmm.0.001021
Title: Invasive paediatric Elizabethkingia meningoseptica infections are best treated with a combination of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or fluoroquinolone
Authors: Chan, JC
Chong, CY 
Thoon, KC 
Tee, NWS 
Maiwald, M 
Lam, JCM
Bhattacharya, R
Chandran, S
Yung, CF
Tan, NWH
Keywords: Science & Technology
Life Sciences & Biomedicine
Microbiology
Elizabethkingia meningoseptica
hospital acquired infection
bacteraemia
meningitis
children
OUTBREAK
PATHOGEN
Issue Date: 1-Aug-2019
Publisher: MICROBIOLOGY SOC
Citation: Chan, JC, Chong, CY, Thoon, KC, Tee, NWS, Maiwald, M, Lam, JCM, Bhattacharya, R, Chandran, S, Yung, CF, Tan, NWH (2019-08-01). Invasive paediatric Elizabethkingia meningoseptica infections are best treated with a combination of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or fluoroquinolone. JOURNAL OF MEDICAL MICROBIOLOGY 68 (8) : 1167-1172. ScholarBank@NUS Repository. https://doi.org/10.1099/jmm.0.001021
Abstract: Objectives. Elizabethkingia meningoseptica is a multi-drug-resistant organism that is associated with high mortality and morbidity in newborn and immunocompromised patients. This study aimed to identify the best antimicrobial therapy for treating this infection. Methods. A retrospective descriptive study was conducted from 2010 to 2017 in a tertiary paediatric hospital in Singapore. Paediatric patients aged 0 to 18 years old with a positive culture for E. meningoseptica from any sterile site were identified from the hospital laboratory database. The data collected included clinical characteristics, antimicrobial susceptibility and treatment, and clinical outcomes. Results. Thirteen cases were identified in this study. Combination therapy with piperacillin/tazobactam and trimethoprim/sulfamethoxazole or a fluoroquinolone resulted in a cure rate of 81.8%. The mortality rate was 15.4% and neurological morbidity in patients with bacteraemia and meningitis remained high (75%). Conclusions. Treatment with combination therapy of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or a fluroquinolone was effective in this study, with low mortality rates being observed.
Source Title: JOURNAL OF MEDICAL MICROBIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/229198
ISSN: 00222615
14735644
DOI: 10.1099/jmm.0.001021
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