Please use this identifier to cite or link to this item: https://doi.org/10.1099/jmm.0.001021
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dc.titleInvasive paediatric Elizabethkingia meningoseptica infections are best treated with a combination of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or fluoroquinolone
dc.contributor.authorChan, JC
dc.contributor.authorChong, CY
dc.contributor.authorThoon, KC
dc.contributor.authorTee, NWS
dc.contributor.authorMaiwald, M
dc.contributor.authorLam, JCM
dc.contributor.authorBhattacharya, R
dc.contributor.authorChandran, S
dc.contributor.authorYung, CF
dc.contributor.authorTan, NWH
dc.date.accessioned2022-07-26T08:06:32Z
dc.date.available2022-07-26T08:06:32Z
dc.date.issued2019-08-01
dc.identifier.citationChan, JC, Chong, CY, Thoon, KC, Tee, NWS, Maiwald, M, Lam, JCM, Bhattacharya, R, Chandran, S, Yung, CF, Tan, NWH (2019-08-01). Invasive paediatric Elizabethkingia meningoseptica infections are best treated with a combination of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or fluoroquinolone. JOURNAL OF MEDICAL MICROBIOLOGY 68 (8) : 1167-1172. ScholarBank@NUS Repository. https://doi.org/10.1099/jmm.0.001021
dc.identifier.issn00222615
dc.identifier.issn14735644
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/229198
dc.description.abstractObjectives. Elizabethkingia meningoseptica is a multi-drug-resistant organism that is associated with high mortality and morbidity in newborn and immunocompromised patients. This study aimed to identify the best antimicrobial therapy for treating this infection. Methods. A retrospective descriptive study was conducted from 2010 to 2017 in a tertiary paediatric hospital in Singapore. Paediatric patients aged 0 to 18 years old with a positive culture for E. meningoseptica from any sterile site were identified from the hospital laboratory database. The data collected included clinical characteristics, antimicrobial susceptibility and treatment, and clinical outcomes. Results. Thirteen cases were identified in this study. Combination therapy with piperacillin/tazobactam and trimethoprim/sulfamethoxazole or a fluoroquinolone resulted in a cure rate of 81.8%. The mortality rate was 15.4% and neurological morbidity in patients with bacteraemia and meningitis remained high (75%). Conclusions. Treatment with combination therapy of piperacillin/tazobactam and trimethoprim/sulfamethoxazole or a fluroquinolone was effective in this study, with low mortality rates being observed.
dc.language.isoen
dc.publisherMICROBIOLOGY SOC
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectMicrobiology
dc.subjectElizabethkingia meningoseptica
dc.subjecthospital acquired infection
dc.subjectbacteraemia
dc.subjectmeningitis
dc.subjectchildren
dc.subjectOUTBREAK
dc.subjectPATHOGEN
dc.typeArticle
dc.date.updated2022-07-21T06:16:56Z
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1099/jmm.0.001021
dc.description.sourcetitleJOURNAL OF MEDICAL MICROBIOLOGY
dc.description.volume68
dc.description.issue8
dc.description.page1167-1172
dc.published.statePublished
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