Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tips.2020.04.007
Title: Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease
Authors: Mei, Dan
Tan, WS Daniel 
Tay, Yvonne 
Mukhopadhyay, Amartya
Wong, WS Fred 
Keywords: Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
ANTISENSE OLIGONUCLEOTIDES
IN-VIVO
COPD
INFLAMMATION
DELIVERY
PATHOGENESIS
PROTECTS
VERSICAN
SMOKERS
ASTHMA
Issue Date: 1-Jul-2020
Publisher: ELSEVIER SCIENCE LONDON
Citation: Mei, Dan, Tan, WS Daniel, Tay, Yvonne, Mukhopadhyay, Amartya, Wong, WS Fred (2020-07-01). Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease. TRENDS IN PHARMACOLOGICAL SCIENCES 41 (7) : 475-486. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tips.2020.04.007
Abstract: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation with persistent respiratory symptoms. Current therapeutics for COPD are largely borrowed from the drug armamentarium for the treatment of asthma, which has different pathophysiological mechanisms from COPD. COPD has been linked to dysregulated expression of mRNAs and noncoding (nc)RNAs including miRNAs, PIWI-interacting (pi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs. This review highlights and discusses some recent advances towards development of RNA therapeutics for COPD.
Source Title: TRENDS IN PHARMACOLOGICAL SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/229051
ISSN: 01656147
18733735
DOI: 10.1016/j.tips.2020.04.007
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