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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tips.2020.04.007
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dc.titleTherapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease
dc.contributor.authorMei, Dan
dc.contributor.authorTan, WS Daniel
dc.contributor.authorTay, Yvonne
dc.contributor.authorMukhopadhyay, Amartya
dc.contributor.authorWong, WS Fred
dc.date.accessioned2022-07-22T03:45:59Z
dc.date.available2022-07-22T03:45:59Z
dc.date.issued2020-07-01
dc.identifier.citationMei, Dan, Tan, WS Daniel, Tay, Yvonne, Mukhopadhyay, Amartya, Wong, WS Fred (2020-07-01). Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease. TRENDS IN PHARMACOLOGICAL SCIENCES 41 (7) : 475-486. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tips.2020.04.007
dc.identifier.issn01656147
dc.identifier.issn18733735
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/229051
dc.description.abstractChronic obstructive pulmonary disease (COPD) is characterized by airflow limitation with persistent respiratory symptoms. Current therapeutics for COPD are largely borrowed from the drug armamentarium for the treatment of asthma, which has different pathophysiological mechanisms from COPD. COPD has been linked to dysregulated expression of mRNAs and noncoding (nc)RNAs including miRNAs, PIWI-interacting (pi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs. This review highlights and discusses some recent advances towards development of RNA therapeutics for COPD.
dc.language.isoen
dc.publisherELSEVIER SCIENCE LONDON
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPharmacology & Pharmacy
dc.subjectANTISENSE OLIGONUCLEOTIDES
dc.subjectIN-VIVO
dc.subjectCOPD
dc.subjectINFLAMMATION
dc.subjectDELIVERY
dc.subjectPATHOGENESIS
dc.subjectPROTECTS
dc.subjectVERSICAN
dc.subjectSMOKERS
dc.subjectASTHMA
dc.typeReview
dc.date.updated2022-07-17T04:00:32Z
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.tips.2020.04.007
dc.description.sourcetitleTRENDS IN PHARMACOLOGICAL SCIENCES
dc.description.volume41
dc.description.issue7
dc.description.page475-486
dc.published.statePublished
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