Please use this identifier to cite or link to this item: https://doi.org/10.1126/science.1092463
Title: EGF-like growth factors as mediators of LH action in the ovulatory follicle
Authors: Park, JY
Su, YQ
Ariga, M
Law, E 
Jin, SLC
Conti, M
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
RECEPTOR LIGANDS
GRANULOSA-CELLS
CUMULUS CELLS
CYCLIC-AMP
OOCYTES
MATURATION
RAT
EXPRESSION
EXPANSION
PATHWAYS
Issue Date: 30-Jan-2004
Publisher: AMER ASSOC ADVANCEMENT SCIENCE
Citation: Park, JY, Su, YQ, Ariga, M, Law, E, Jin, SLC, Conti, M (2004-01-30). EGF-like growth factors as mediators of LH action in the ovulatory follicle. SCIENCE 303 (5658) : 682-684. ScholarBank@NUS Repository. https://doi.org/10.1126/science.1092463
Abstract: Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.
Source Title: SCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/228858
ISSN: 00368075
10959203
DOI: 10.1126/science.1092463
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