Please use this identifier to cite or link to this item:
https://doi.org/10.1126/science.1092463
DC Field | Value | |
---|---|---|
dc.title | EGF-like growth factors as mediators of LH action in the ovulatory follicle | |
dc.contributor.author | Park, JY | |
dc.contributor.author | Su, YQ | |
dc.contributor.author | Ariga, M | |
dc.contributor.author | Law, E | |
dc.contributor.author | Jin, SLC | |
dc.contributor.author | Conti, M | |
dc.date.accessioned | 2022-07-20T01:23:03Z | |
dc.date.available | 2022-07-20T01:23:03Z | |
dc.date.issued | 2004-01-30 | |
dc.identifier.citation | Park, JY, Su, YQ, Ariga, M, Law, E, Jin, SLC, Conti, M (2004-01-30). EGF-like growth factors as mediators of LH action in the ovulatory follicle. SCIENCE 303 (5658) : 682-684. ScholarBank@NUS Repository. https://doi.org/10.1126/science.1092463 | |
dc.identifier.issn | 00368075 | |
dc.identifier.issn | 10959203 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/228858 | |
dc.description.abstract | Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle. | |
dc.language.iso | en | |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Multidisciplinary Sciences | |
dc.subject | Science & Technology - Other Topics | |
dc.subject | RECEPTOR LIGANDS | |
dc.subject | GRANULOSA-CELLS | |
dc.subject | CUMULUS CELLS | |
dc.subject | CYCLIC-AMP | |
dc.subject | OOCYTES | |
dc.subject | MATURATION | |
dc.subject | RAT | |
dc.subject | EXPRESSION | |
dc.subject | EXPANSION | |
dc.subject | PATHWAYS | |
dc.type | Article | |
dc.date.updated | 2022-07-16T01:15:58Z | |
dc.contributor.department | PAEDIATRICS | |
dc.description.doi | 10.1126/science.1092463 | |
dc.description.sourcetitle | SCIENCE | |
dc.description.volume | 303 | |
dc.description.issue | 5658 | |
dc.description.page | 682-684 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Science EGF.pdf | Published version | 1.1 MB | Adobe PDF | CLOSED | Published |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.