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Title: A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.
Authors: Parikh, Bhav Harshad
Liu, Zengping 
Blakeley, Paul 
Lin, Qianyu
Singh, Malay
Ong, Jun Yi
Ho, Kim Han
Lai, Joel Weijia
Bogireddi, Hanumakumar
Tran, Kim Chi 
Lim, Jason YC
Xue, Kun
Al-Mubaarak, Abdurrahmaan
Yang, Binxia
R, Sowmiya
Regha, Kakkad
Wong, Daniel Soo Lin
Tan, Queenie Shu Woon
Zhang, Zhongxing 
Jeyasekharan, Anand D 
Barathi, Veluchamy Amutha
Yu, Weimiao
Cheong, Kang Hao
Blenkinsop, Timothy A
Hunziker, Walter
Lingam, Gopal 
Loh, Xian Jun 
Su, Xinyi
Keywords: Animals
Cell Line
Cell Movement
Epithelial-Mesenchymal Transition
NF-E2-Related Factor 2
Retinal Pigment Epithelium
Issue Date: 19-May-2022
Publisher: Springer Science and Business Media LLC
Citation: Parikh, Bhav Harshad, Liu, Zengping, Blakeley, Paul, Lin, Qianyu, Singh, Malay, Ong, Jun Yi, Ho, Kim Han, Lai, Joel Weijia, Bogireddi, Hanumakumar, Tran, Kim Chi, Lim, Jason YC, Xue, Kun, Al-Mubaarak, Abdurrahmaan, Yang, Binxia, R, Sowmiya, Regha, Kakkad, Wong, Daniel Soo Lin, Tan, Queenie Shu Woon, Zhang, Zhongxing, Jeyasekharan, Anand D, Barathi, Veluchamy Amutha, Yu, Weimiao, Cheong, Kang Hao, Blenkinsop, Timothy A, Hunziker, Walter, Lingam, Gopal, Loh, Xian Jun, Su, Xinyi (2022-05-19). A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.. Nat Commun 13 (1) : 2796-. ScholarBank@NUS Repository.
Abstract: One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-proliferation of retinal pigment epithelial (RPE) cells. Current treatment relies primarily on surgical removal of these membranes. Here, we demonstrate that a bio-functional polymer by itself is able to prevent retinal scarring in an experimental rabbit model of proliferative vitreoretinopathy. This is mediated primarily via clathrin-dependent internalisation of polymeric micelles, downstream suppression of canonical EMT transcription factors, reduction of RPE cell hyper-proliferation and migration. Nuclear factor erythroid 2-related factor 2 signalling pathway was identified in a genome-wide transcriptomic profiling as a key sensor and effector. This study highlights the potential of using synthetic bio-functional polymer to modulate RPE cellular behaviour and offers a potential therapy for retinal scarring prevention.
Source Title: Nat Commun
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30474-6
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