Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41467-022-30474-6
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dc.title | A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway. | |
dc.contributor.author | Parikh, Bhav Harshad | |
dc.contributor.author | Liu, Zengping | |
dc.contributor.author | Blakeley, Paul | |
dc.contributor.author | Lin, Qianyu | |
dc.contributor.author | Singh, Malay | |
dc.contributor.author | Ong, Jun Yi | |
dc.contributor.author | Ho, Kim Han | |
dc.contributor.author | Lai, Joel Weijia | |
dc.contributor.author | Bogireddi, Hanumakumar | |
dc.contributor.author | Tran, Kim Chi | |
dc.contributor.author | Lim, Jason YC | |
dc.contributor.author | Xue, Kun | |
dc.contributor.author | Al-Mubaarak, Abdurrahmaan | |
dc.contributor.author | Yang, Binxia | |
dc.contributor.author | R, Sowmiya | |
dc.contributor.author | Regha, Kakkad | |
dc.contributor.author | Wong, Daniel Soo Lin | |
dc.contributor.author | Tan, Queenie Shu Woon | |
dc.contributor.author | Zhang, Zhongxing | |
dc.contributor.author | Jeyasekharan, Anand D | |
dc.contributor.author | Barathi, Veluchamy Amutha | |
dc.contributor.author | Yu, Weimiao | |
dc.contributor.author | Cheong, Kang Hao | |
dc.contributor.author | Blenkinsop, Timothy A | |
dc.contributor.author | Hunziker, Walter | |
dc.contributor.author | Lingam, Gopal | |
dc.contributor.author | Loh, Xian Jun | |
dc.contributor.author | Su, Xinyi | |
dc.date.accessioned | 2022-07-15T01:03:20Z | |
dc.date.available | 2022-07-15T01:03:20Z | |
dc.date.issued | 2022-05-19 | |
dc.identifier.citation | Parikh, Bhav Harshad, Liu, Zengping, Blakeley, Paul, Lin, Qianyu, Singh, Malay, Ong, Jun Yi, Ho, Kim Han, Lai, Joel Weijia, Bogireddi, Hanumakumar, Tran, Kim Chi, Lim, Jason YC, Xue, Kun, Al-Mubaarak, Abdurrahmaan, Yang, Binxia, R, Sowmiya, Regha, Kakkad, Wong, Daniel Soo Lin, Tan, Queenie Shu Woon, Zhang, Zhongxing, Jeyasekharan, Anand D, Barathi, Veluchamy Amutha, Yu, Weimiao, Cheong, Kang Hao, Blenkinsop, Timothy A, Hunziker, Walter, Lingam, Gopal, Loh, Xian Jun, Su, Xinyi (2022-05-19). A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.. Nat Commun 13 (1) : 2796-. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-022-30474-6 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/228597 | |
dc.description.abstract | One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-proliferation of retinal pigment epithelial (RPE) cells. Current treatment relies primarily on surgical removal of these membranes. Here, we demonstrate that a bio-functional polymer by itself is able to prevent retinal scarring in an experimental rabbit model of proliferative vitreoretinopathy. This is mediated primarily via clathrin-dependent internalisation of polymeric micelles, downstream suppression of canonical EMT transcription factors, reduction of RPE cell hyper-proliferation and migration. Nuclear factor erythroid 2-related factor 2 signalling pathway was identified in a genome-wide transcriptomic profiling as a key sensor and effector. This study highlights the potential of using synthetic bio-functional polymer to modulate RPE cellular behaviour and offers a potential therapy for retinal scarring prevention. | |
dc.publisher | Springer Science and Business Media LLC | |
dc.source | Elements | |
dc.subject | Animals | |
dc.subject | Cell Line | |
dc.subject | Cell Movement | |
dc.subject | Cicatrix | |
dc.subject | Epithelial-Mesenchymal Transition | |
dc.subject | NF-E2-Related Factor 2 | |
dc.subject | Polymers | |
dc.subject | Rabbits | |
dc.subject | Retinal Pigment Epithelium | |
dc.type | Article | |
dc.date.updated | 2022-07-13T09:59:29Z | |
dc.contributor.department | MATERIALS SCIENCE AND ENGINEERING | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.contributor.department | DIVISION OF BIOENGINEERING | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1038/s41467-022-30474-6 | |
dc.description.sourcetitle | Nat Commun | |
dc.description.volume | 13 | |
dc.description.issue | 1 | |
dc.description.page | 2796- | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway.pdf | 10.74 MB | Adobe PDF | OPEN | Published | View/Download |
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