Please use this identifier to cite or link to this item: https://doi.org/10.3389/fonc.2021.763229
Title: A Systematic Review and Meta-Analysis of the Effectiveness of Neuroprotectants for Paclitaxel-Induced Peripheral Neuropathy
Authors: Leen, AJ
Yap, DWT
Teo, CB
Tan, BKJ
Molassiotis, A
Ishiguro, H
Fan, SWX 
Sundar, R 
Soon, YY
Bandla, A 
Keywords: chemotherapy-induced peripheral neuropathy (CIPN)
neuroprotection
non-invasive
paclitaxel-induced peripheral neuropathy
prevention
taxane
Issue Date: 5-Jan-2022
Publisher: Frontiers Media SA
Citation: Leen, AJ, Yap, DWT, Teo, CB, Tan, BKJ, Molassiotis, A, Ishiguro, H, Fan, SWX, Sundar, R, Soon, YY, Bandla, A (2022-01-05). A Systematic Review and Meta-Analysis of the Effectiveness of Neuroprotectants for Paclitaxel-Induced Peripheral Neuropathy. Frontiers in Oncology 11 : 763229-. ScholarBank@NUS Repository. https://doi.org/10.3389/fonc.2021.763229
Abstract: Background: Paclitaxel-induced peripheral neuropathy (PIPN) is a disabling side effect of paclitaxel with few effective preventive strategies. We aim to determine the efficacy of pharmacological and non-pharmacological neuroprotective interventions in preventing PIPN incidence. Methods: Biomedical literature databases were searched from years 2000 to 2021 for trials comparing neuroprotective interventions and control. Meta-analysis was performed using the random-effects model. The primary outcome was the incidence of PIPN. Results: Of 24 relevant controlled trials, 14 were eligible for meta-analysis. Pooled results from seven non-pharmacological trials were associated with a statistically significant 48% relative reduction of PIPN risk with low heterogeneity. Conversely, pooled results from six pharmacological trials were associated with a significant 20% relative reduction of PIPN risk with moderate heterogeneity. Both pharmacological and non-pharmacological approaches appear effective in reducing PIPN incidence in the treatment arm compared to control (pooled RR < 1). Conclusion: Current evidence suggests that both interventions may reduce PIPN risk. Non-pharmacological interventions appear more effective than pharmacological interventions.
Source Title: Frontiers in Oncology
URI: https://scholarbank.nus.edu.sg/handle/10635/228503
ISSN: 2234-943X
DOI: 10.3389/fonc.2021.763229
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