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Title: BREAst screening Tailored for HEr (BREATHE)-A study protocol on personalised risk-based breast cancer screening programme
Authors: Liu, Jenny 
Ho, Peh Joo
Tan, Tricia Hui Ling
Yeoh, Yen Shing 
Chew, Ying Jia
Riza, Nur Khaliesah Mohamed 
Khng, Alexis Jiaying
Goh, Su-Ann 
Wang, Yi 
Oh, Han Boon
Chin, Chi Hui
Kwek, Sing Cheer
Zhang, Zhi Peng
Ong, Desmond Luan Seng
Quek, Swee Tian 
Tan, Chuan Chien
Wee, Hwee Lin 
Li, Jingmei 
Iau, Philip Tsau Choong
Hartman, Mikael 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Issue Date: 31-Mar-2022
Citation: Liu, Jenny, Ho, Peh Joo, Tan, Tricia Hui Ling, Yeoh, Yen Shing, Chew, Ying Jia, Riza, Nur Khaliesah Mohamed, Khng, Alexis Jiaying, Goh, Su-Ann, Wang, Yi, Oh, Han Boon, Chin, Chi Hui, Kwek, Sing Cheer, Zhang, Zhi Peng, Ong, Desmond Luan Seng, Quek, Swee Tian, Tan, Chuan Chien, Wee, Hwee Lin, Li, Jingmei, Iau, Philip Tsau Choong, Hartman, Mikael (2022-03-31). BREAst screening Tailored for HEr (BREATHE)-A study protocol on personalised risk-based breast cancer screening programme. PLOS ONE 17 (3). ScholarBank@NUS Repository.
Abstract: Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment is most successful. Current breast screening programmes are one-size-fits-all which all women above a certain age threshold are encouraged to participate. However, breast cancer risk varies by individual. The BREAst screening Tailored for HEr (BREATHE) study aims to assess acceptability of a comprehensive risk-based personalised breast screening in Singapore. Advancing beyond the current age-based screening paradigm, BREATHE integrates both genetic and non-genetic breast cancer risk prediction tools to personalise screening recommendations. BREATHE is a cohort study targeting to recruit ~3,500 women. The first recruitment visit will include questionnaires and a buccal cheek swab. After receiving a tailored breast cancer risk report, participants will attend an in-person risk review, followed by a final session assessing the acceptability of our risk stratification programme. Risk prediction is based on: a) Gail model (non-genetic), b) mammographic density and recall, c) BOADICEA predictions (breast cancer predisposition genes), and d) breast cancer polygenic risk score. For national implementation of personalised risk-based breast screening, exploration of the acceptability within the target populace is critical, in addition to validated predication tools. To our knowledge, this is the first study to implement a comprehensive risk-based mammography screening programme in Asia. The BREATHE study will provide essential data for policy implementation which will transform the health system to deliver a better health and healthcare outcomes.
Source Title: PLOS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0265965
Appears in Collections:Staff Publications

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