Please use this identifier to cite or link to this item: https://doi.org/10.1183/13993003.00766-2018
Title: Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study
Authors: Mac Aogain, Micheal
Chandrasekaran, Ravishankar
Lim, Albert Yick Hou
Low, Teck Boon
Tan, Gan Liang 
Hassan, Tidi
Thun, How Ong
Ng, Amanda Hui Qi
Bertrand, Denis
Koh, Jia Yu
Pang, Sze Lei 
Lee, Zi Yang 
Gwee, Xiao Wei 
Martinus, Christopher
Sio, Yang Yie 
Matta, Sri Anusha
Chew, Fook Tim 
Keir, Holly R
Connolly, John E 
Abisheganaden, John Arputhan
Koh, Mariko Siyue
Nagarajan, Niranjan
Chalmers, James D
Chotirmall, Sanjay H
Keywords: Science & Technology
Life Sciences & Biomedicine
Respiratory System
ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS
CYSTIC-FIBROSIS
TERREUS
COLONIZATION
EXACERBATIONS
DISEASE
CLASSIFICATION
SENSITIZATION
PATHOGENESIS
INFECTIONS
Issue Date: 1-Jul-2018
Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD
Citation: Mac Aogain, Micheal, Chandrasekaran, Ravishankar, Lim, Albert Yick Hou, Low, Teck Boon, Tan, Gan Liang, Hassan, Tidi, Thun, How Ong, Ng, Amanda Hui Qi, Bertrand, Denis, Koh, Jia Yu, Pang, Sze Lei, Lee, Zi Yang, Gwee, Xiao Wei, Martinus, Christopher, Sio, Yang Yie, Matta, Sri Anusha, Chew, Fook Tim, Keir, Holly R, Connolly, John E, Abisheganaden, John Arputhan, Koh, Mariko Siyue, Nagarajan, Niranjan, Chalmers, James D, Chotirmall, Sanjay H (2018-07-01). Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study. EUROPEAN RESPIRATORY JOURNAL 52 (1). ScholarBank@NUS Repository. https://doi.org/10.1183/13993003.00766-2018
Abstract: Understanding the composition and clinical importance of the fungal mycobiome was recently identified as a key topic in a “research priorities” consensus statement for bronchiectasis. Patients were recruited as part of the CAMEB study: an international multicentre cross-sectional Cohort of Asian and Matched European Bronchiectasis patients. The mycobiome was determined in 238 patients by targeted amplicon shotgun sequencing of the 18S–28S rRNA internally transcribed spacer regions ITS1 and ITS2. Specific quantitative PCR for detection of and conidial quantification for a range of airway Aspergillus species was performed. Sputum galactomannan, Aspergillus specific IgE, IgG and TARC (thymus and activation regulated chemokine) levels were measured systemically and associated to clinical outcomes. The bronchiectasis mycobiome is distinct and characterised by specific fungal genera, including Aspergillus, Cryptococcus and Clavispora. Aspergillus fumigatus (in Singapore/Kuala Lumpur) and Aspergillus terreus (in Dundee) dominated profiles, the latter associating with exacerbations. High frequencies of Aspergillus-associated disease including sensitisation and allergic bronchopulmonary aspergillosis were detected. Each revealed distinct mycobiome profiles, and associated with more severe disease, poorer pulmonary function and increased exacerbations. The pulmonary mycobiome is of clinical relevance in bronchiectasis. Screening for Aspergillus-associated disease should be considered even in apparently stable patients.
Source Title: EUROPEAN RESPIRATORY JOURNAL
URI: https://scholarbank.nus.edu.sg/handle/10635/227040
ISSN: 0903-1936
1399-3003
DOI: 10.1183/13993003.00766-2018
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