Please use this identifier to cite or link to this item: https://doi.org/10.1183/13993003.00766-2018
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dc.titleImmunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study
dc.contributor.authorMac Aogain, Micheal
dc.contributor.authorChandrasekaran, Ravishankar
dc.contributor.authorLim, Albert Yick Hou
dc.contributor.authorLow, Teck Boon
dc.contributor.authorTan, Gan Liang
dc.contributor.authorHassan, Tidi
dc.contributor.authorThun, How Ong
dc.contributor.authorNg, Amanda Hui Qi
dc.contributor.authorBertrand, Denis
dc.contributor.authorKoh, Jia Yu
dc.contributor.authorPang, Sze Lei
dc.contributor.authorLee, Zi Yang
dc.contributor.authorGwee, Xiao Wei
dc.contributor.authorMartinus, Christopher
dc.contributor.authorSio, Yang Yie
dc.contributor.authorMatta, Sri Anusha
dc.contributor.authorChew, Fook Tim
dc.contributor.authorKeir, Holly R
dc.contributor.authorConnolly, John E
dc.contributor.authorAbisheganaden, John Arputhan
dc.contributor.authorKoh, Mariko Siyue
dc.contributor.authorNagarajan, Niranjan
dc.contributor.authorChalmers, James D
dc.contributor.authorChotirmall, Sanjay H
dc.date.accessioned2022-06-13T09:10:38Z
dc.date.available2022-06-13T09:10:38Z
dc.date.issued2018-07-27
dc.identifier.citationMac Aogain, Micheal, Chandrasekaran, Ravishankar, Lim, Albert Yick Hou, Low, Teck Boon, Tan, Gan Liang, Hassan, Tidi, Thun, How Ong, Ng, Amanda Hui Qi, Bertrand, Denis, Koh, Jia Yu, Pang, Sze Lei, Lee, Zi Yang, Gwee, Xiao Wei, Martinus, Christopher, Sio, Yang Yie, Matta, Sri Anusha, Chew, Fook Tim, Keir, Holly R, Connolly, John E, Abisheganaden, John Arputhan, Koh, Mariko Siyue, Nagarajan, Niranjan, Chalmers, James D, Chotirmall, Sanjay H (2018-07-27). Immunological corollary of the pulmonary mycobiome in bronchiectasis: the CAMEB study. EUROPEAN RESPIRATORY JOURNAL 52 (1). ScholarBank@NUS Repository. https://doi.org/10.1183/13993003.00766-2018
dc.identifier.issn0903-1936
dc.identifier.issn1399-3003
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/227040
dc.description.abstractUnderstanding the composition and clinical importance of the fungal mycobiome was recently identified as a key topic in a “research priorities” consensus statement for bronchiectasis. Patients were recruited as part of the CAMEB study: an international multicentre cross-sectional Cohort of Asian and Matched European Bronchiectasis patients. The mycobiome was determined in 238 patients by targeted amplicon shotgun sequencing of the 18S–28S rRNA internally transcribed spacer regions ITS1 and ITS2. Specific quantitative PCR for detection of and conidial quantification for a range of airway Aspergillus species was performed. Sputum galactomannan, Aspergillus specific IgE, IgG and TARC (thymus and activation regulated chemokine) levels were measured systemically and associated to clinical outcomes. The bronchiectasis mycobiome is distinct and characterised by specific fungal genera, including Aspergillus, Cryptococcus and Clavispora. Aspergillus fumigatus (in Singapore/Kuala Lumpur) and Aspergillus terreus (in Dundee) dominated profiles, the latter associating with exacerbations. High frequencies of Aspergillus-associated disease including sensitisation and allergic bronchopulmonary aspergillosis were detected. Each revealed distinct mycobiome profiles, and associated with more severe disease, poorer pulmonary function and increased exacerbations. The pulmonary mycobiome is of clinical relevance in bronchiectasis. Screening for Aspergillus-associated disease should be considered even in apparently stable patients.
dc.language.isoen
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectRespiratory System
dc.subjectALLERGIC BRONCHOPULMONARY ASPERGILLOSIS
dc.subjectCYSTIC-FIBROSIS
dc.subjectTERREUS
dc.subjectCOLONIZATION
dc.subjectEXACERBATIONS
dc.subjectDISEASE
dc.subjectCLASSIFICATION
dc.subjectSENSITIZATION
dc.subjectPATHOGENESIS
dc.subjectINFECTIONS
dc.typeArticle
dc.date.updated2022-06-10T02:33:17Z
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentDEAN'S OFFICE (SCIENCE)
dc.contributor.departmentDEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH)
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1183/13993003.00766-2018
dc.description.sourcetitleEUROPEAN RESPIRATORY JOURNAL
dc.description.volume52
dc.description.issue1
dc.published.statePublished
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