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Title: Highly deregulated lncRNA LOC is associated with overall worse prognosis in Hepatocellular Carcinoma patients
Authors: Lim, Lee Jin 
Ling, Lay Hiang 
Neo, Yu Pei
Chung, Alexander YF 
Goh, Brian KP 
Chow, Pierce KH 
Chan, Chung Yip 
Cheow, Peng Chung 
Lee, Ser Yee 
Lim, Tony KH
Chong, Samuel S 
Ooi, London LPJ 
Lee, Caroline G 
Keywords: Science & Technology
Life Sciences & Biomedicine
Hepatocellular Carcinoma
Long non-coding RNA
Issue Date: 1-Jan-2021
Citation: Lim, Lee Jin, Ling, Lay Hiang, Neo, Yu Pei, Chung, Alexander YF, Goh, Brian KP, Chow, Pierce KH, Chan, Chung Yip, Cheow, Peng Chung, Lee, Ser Yee, Lim, Tony KH, Chong, Samuel S, Ooi, London LPJ, Lee, Caroline G (2021-01-01). Highly deregulated lncRNA LOC is associated with overall worse prognosis in Hepatocellular Carcinoma patients. JOURNAL OF CANCER 12 (11) : 3098-3113. ScholarBank@NUS Repository.
Abstract: Although numerous long non-coding RNAs (lncRNAs) were reported to be deregulated in Hepatocellular Carcinoma (HCC), experimentally characterized, and/or associated with patient's clinical characteristics, there is, thus far, minimal concerted research strategy to identify deregulated lncRNAs that modulate prognosis of HCC patients. Here, we present a novel strategy where we identify lncRNAs, which are not only de-regulated in HCC patients, but are also associated with pertinent clinical characteristics, potentially contributing to the prognosis of HCC patients. LOC101926913 (LOC) was further characterized because it is the most highly differentially expressed amongst those that are associated with the most number of clinical features (tumor-stage, vascular and tumor invasion and poorer overall survival). Experimental gain- and loss-of-function manipulation of LOC in liver cell-lines highlight LOC as a potential onco-lncRNA promoting cell proliferation, anchorage independent growth and invasion. LOC expression in cells up-regulated genes involved in GTPase-activities and downregulated genes associated with cellular detoxification, oxygen- and drug-transport. Hence, LOC may represent a novel therapeutic target, modulating prognosis of HCC patients through up-regulating GTPase-activities and down-regulating detoxification, oxygen- and drug-transport. This strategy may thus be useful for the identification of clinically relevant lncRNAs as potential biomarkers/targets that modulate prognosis in other cancers as well.
ISSN: 1837
DOI: 10.7150/jca.56340
Appears in Collections:Staff Publications

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