Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.isci.2021.102434
Title: | Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue | Authors: | Yau, Winifred W Wong, Kiraely Adam Zhou, Jin Thimmukonda, Nivetha Kanakaram Wu, Yajun Bay, Boon-Huat Singh, Brijesh Kumar Yen, Paul Michael |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics THYROID-HORMONE MITOPHAGY ADIPOCYTES ANGIOGENESIS ACCLIMATION HOMEOSTASIS ACTIVATION PROTEIN MICE |
Issue Date: | 21-May-2021 | Publisher: | CELL PRESS | Citation: | Yau, Winifred W, Wong, Kiraely Adam, Zhou, Jin, Thimmukonda, Nivetha Kanakaram, Wu, Yajun, Bay, Boon-Huat, Singh, Brijesh Kumar, Yen, Paul Michael (2021-05-21). Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue. ISCIENCE 24 (5). ScholarBank@NUS Repository. https://doi.org/10.1016/j.isci.2021.102434 | Abstract: | Autophagy plays an important role in lipid breakdown, mitochondrial turnover, and mitochondrial function during brown adipose tissue (BAT) activation by thyroid hormone, but its role in BAT during adaptive thermogenesis remains controversial. Here, we examined BAT from mice exposed to 72 h of cold challenge as well as primary brown adipocytes treated with norepinephrine and found increased autophagy as well as increased β-oxidation, mitophagy, mitochondrial turnover, and mitochondrial activity. To further understand the role of autophagy of BAT in vivo, we generated BAT-specific Atg5 knockout (Atg5cKO) mice and exposed them to cold for 72 h. Interestingly, BAT-specific Atg5cKO mice were unable to maintain body temperature after chronic cold exposure and displayed deranged mitochondrial morphology and reactive oxygen species damage in their BAT. Our findings demonstrate the critical role of autophagy in adaptive thermogenesis, fatty acid metabolism, and mitochondrial function in BAT during chronic cold exposure. | Source Title: | ISCIENCE | URI: | https://scholarbank.nus.edu.sg/handle/10635/226683 | ISSN: | 25890042 | DOI: | 10.1016/j.isci.2021.102434 |
Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown .pdf | Published version | 3.18 MB | Adobe PDF | OPEN | Published | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.