Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.isci.2021.102434
Title: Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue
Authors: Yau, Winifred W 
Wong, Kiraely Adam 
Zhou, Jin 
Thimmukonda, Nivetha Kanakaram 
Wu, Yajun 
Bay, Boon-Huat 
Singh, Brijesh Kumar 
Yen, Paul Michael 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
THYROID-HORMONE
MITOPHAGY
ADIPOCYTES
ANGIOGENESIS
ACCLIMATION
HOMEOSTASIS
ACTIVATION
PROTEIN
MICE
Issue Date: 21-May-2021
Publisher: CELL PRESS
Citation: Yau, Winifred W, Wong, Kiraely Adam, Zhou, Jin, Thimmukonda, Nivetha Kanakaram, Wu, Yajun, Bay, Boon-Huat, Singh, Brijesh Kumar, Yen, Paul Michael (2021-05-21). Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue. ISCIENCE 24 (5). ScholarBank@NUS Repository. https://doi.org/10.1016/j.isci.2021.102434
Abstract: Autophagy plays an important role in lipid breakdown, mitochondrial turnover, and mitochondrial function during brown adipose tissue (BAT) activation by thyroid hormone, but its role in BAT during adaptive thermogenesis remains controversial. Here, we examined BAT from mice exposed to 72 h of cold challenge as well as primary brown adipocytes treated with norepinephrine and found increased autophagy as well as increased β-oxidation, mitophagy, mitochondrial turnover, and mitochondrial activity. To further understand the role of autophagy of BAT in vivo, we generated BAT-specific Atg5 knockout (Atg5cKO) mice and exposed them to cold for 72 h. Interestingly, BAT-specific Atg5cKO mice were unable to maintain body temperature after chronic cold exposure and displayed deranged mitochondrial morphology and reactive oxygen species damage in their BAT. Our findings demonstrate the critical role of autophagy in adaptive thermogenesis, fatty acid metabolism, and mitochondrial function in BAT during chronic cold exposure.
Source Title: ISCIENCE
URI: https://scholarbank.nus.edu.sg/handle/10635/226683
ISSN: 25890042
DOI: 10.1016/j.isci.2021.102434
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