Please use this identifier to cite or link to this item: https://doi.org/10.3389/fmicb.2021.663642
Title: Biosynthesis of Commodity Chemicals From Oil Palm Empty Fruit Bunch Lignin
Authors: Lo, Tat-Ming 
Hwang, In Young 
Cho, Han-Saem 
Fedora, Raissa Eka 
Chng, Si Hui 
Choi, Won Jae 
Chang, Matthew Wook 
Keywords: Science & Technology
Life Sciences & Biomedicine
Microbiology
direct biosynthesis
commodity chemicals
metabolic engineering
oil palm empty fruit bunch
lignin
synthetic biology
Issue Date: 9-Apr-2021
Publisher: FRONTIERS MEDIA SA
Citation: Lo, Tat-Ming, Hwang, In Young, Cho, Han-Saem, Fedora, Raissa Eka, Chng, Si Hui, Choi, Won Jae, Chang, Matthew Wook (2021-04-09). Biosynthesis of Commodity Chemicals From Oil Palm Empty Fruit Bunch Lignin. FRONTIERS IN MICROBIOLOGY 12. ScholarBank@NUS Repository. https://doi.org/10.3389/fmicb.2021.663642
Abstract: Lignin is one of the most abundant natural resources that can be exploited for the bioproduction of value-added commodity chemicals. Oil palm empty fruit bunches (OPEFBs), byproducts of palm oil production, are abundant lignocellulosic biomass but largely used for energy and regarded as waste. Pretreatment of OPEFB lignin can yield a mixture of aromatic compounds that can potentially serve as substrates to produce commercially important chemicals. However, separation of the mixture into desired individual substrates is required, which involves expensive steps that undermine the utility of OPEFB lignin. Here, we report successful engineering of microbial hosts that can directly utilize heterogeneous mixtures derived from OPEFB lignin to produce commodity chemicals, adipic acid and levulinic acid. Furthermore, the corresponding bioconversion pathway was placed under a genetic controller to autonomously activate the conversion process as the cells are fed with a depolymerized OPEFB lignin mixture. This study demonstrates a simple, one-pot biosynthesis approach that directly utilizes derivatives of agricultural waste to produce commodity chemicals.
Source Title: FRONTIERS IN MICROBIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/226654
ISSN: 1664-302X
DOI: 10.3389/fmicb.2021.663642
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