Please use this identifier to cite or link to this item: https://doi.org/10.3389/fmicb.2021.663642
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dc.titleBiosynthesis of Commodity Chemicals From Oil Palm Empty Fruit Bunch Lignin
dc.contributor.authorLo, Tat-Ming
dc.contributor.authorHwang, In Young
dc.contributor.authorCho, Han-Saem
dc.contributor.authorFedora, Raissa Eka
dc.contributor.authorChng, Si Hui
dc.contributor.authorChoi, Won Jae
dc.contributor.authorChang, Matthew Wook
dc.date.accessioned2022-06-07T09:01:56Z
dc.date.available2022-06-07T09:01:56Z
dc.date.issued2021-04-09
dc.identifier.citationLo, Tat-Ming, Hwang, In Young, Cho, Han-Saem, Fedora, Raissa Eka, Chng, Si Hui, Choi, Won Jae, Chang, Matthew Wook (2021-04-09). Biosynthesis of Commodity Chemicals From Oil Palm Empty Fruit Bunch Lignin. FRONTIERS IN MICROBIOLOGY 12. ScholarBank@NUS Repository. https://doi.org/10.3389/fmicb.2021.663642
dc.identifier.issn1664-302X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/226654
dc.description.abstractLignin is one of the most abundant natural resources that can be exploited for the bioproduction of value-added commodity chemicals. Oil palm empty fruit bunches (OPEFBs), byproducts of palm oil production, are abundant lignocellulosic biomass but largely used for energy and regarded as waste. Pretreatment of OPEFB lignin can yield a mixture of aromatic compounds that can potentially serve as substrates to produce commercially important chemicals. However, separation of the mixture into desired individual substrates is required, which involves expensive steps that undermine the utility of OPEFB lignin. Here, we report successful engineering of microbial hosts that can directly utilize heterogeneous mixtures derived from OPEFB lignin to produce commodity chemicals, adipic acid and levulinic acid. Furthermore, the corresponding bioconversion pathway was placed under a genetic controller to autonomously activate the conversion process as the cells are fed with a depolymerized OPEFB lignin mixture. This study demonstrates a simple, one-pot biosynthesis approach that directly utilizes derivatives of agricultural waste to produce commodity chemicals.
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectMicrobiology
dc.subjectdirect biosynthesis
dc.subjectcommodity chemicals
dc.subjectmetabolic engineering
dc.subjectoil palm empty fruit bunch
dc.subjectlignin
dc.subjectsynthetic biology
dc.typeArticle
dc.date.updated2022-06-07T01:27:23Z
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.3389/fmicb.2021.663642
dc.description.sourcetitleFRONTIERS IN MICROBIOLOGY
dc.description.volume12
dc.published.statePublished
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