Please use this identifier to cite or link to this item: https://doi.org/10.21203/rs.2.23593/v1
Title: Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study
Authors: Goh, Jorming 
Hofmann, Peter
Aw, Ning Hong
Tan, Poh Ling 
Tschakert, Gerhard
Mueller, Alexander
Wong, Siew Cheng 
Tan, Frankie 
Gan, Linda Seo Hwee
Keywords: Exercise
Alarmins
HMGB1
S100A8/A9
HSP70
sRAGE
Issue Date: Dec-2020
Publisher: Springer Science and Business Media LLC
Citation: Goh, Jorming, Hofmann, Peter, Aw, Ning Hong, Tan, Poh Ling, Tschakert, Gerhard, Mueller, Alexander, Wong, Siew Cheng, Tan, Frankie, Gan, Linda Seo Hwee (2020-12). Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study. Translational Medicine Communications 5 (1). ScholarBank@NUS Repository. https://doi.org/10.21203/rs.2.23593/v1
Abstract: Abstract Background: Intense exercise is a systemic stressor associated with the release of “danger” molecules – alarmins, by damaged or dying cells into systemic circulation to evoke a sterile inflammatory response. Compared with research in clinical diseases, physiological responses of alarmins to exercise and training are not well studied. Short-term responses to exercise and training using a panel of alarmins – HMGB1, S100A8/A9, HSP70 and sRAGE may reveal unique aspects of stress responses to strenuous exercise with important ramifications when prescribing exercise to generally healthy adults. Methods: A 3-week, high-intensity training program was performed by healthy young men (N = 7). Concurrent aerobic and resistance exercises were performed on 3 consecutive days each week. Blood and saliva were collected before (Pre), immediately after (Post), and 30 min (30 min) after exercise each week, and 24 h after the final exercise session in week 3 (24 h). Results: Plasma HMGB1, S100A8/A9 and HSP70 increased from Pre to Post (P < 0.05), although at different timepoints during the study, and displayed different kinetics from IL-10, IL-8 and IFN-γ, suggesting unique mechanisms involved in modulating their release and clearance. CD14+CD16- monocytes increased from Pre to Post across 3 weeks; CD14+CD16+ monocytes increased from Pre to Post in week 2 and 3 (P < 0.05). ΔHMGB1 and ΔHSP70 correlated positively with ΔMCP-1 during 3 weeks of training, while ΔHMGB1 correlated positively with CD14+CD16- monocytes, suggesting higher alarmin release after strenuous exercise may involve increase in circulating monocytes. Conclusions: Perturbations in systemic alarmins are novel biological signatures for assessing the inflammatory milieu of healthy adults during high-intensity exercise.
Source Title: Translational Medicine Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/219451
ISSN: 2396-832X
DOI: 10.21203/rs.2.23593/v1
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