Please use this identifier to cite or link to this item:
https://doi.org/10.21203/rs.2.23593/v1
DC Field | Value | |
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dc.title | Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study | |
dc.contributor.author | Goh, Jorming | |
dc.contributor.author | Hofmann, Peter | |
dc.contributor.author | Aw, Ning Hong | |
dc.contributor.author | Tan, Poh Ling | |
dc.contributor.author | Tschakert, Gerhard | |
dc.contributor.author | Mueller, Alexander | |
dc.contributor.author | Wong, Siew Cheng | |
dc.contributor.author | Tan, Frankie | |
dc.contributor.author | Gan, Linda Seo Hwee | |
dc.date.accessioned | 2022-04-21T08:46:20Z | |
dc.date.available | 2022-04-21T08:46:20Z | |
dc.date.issued | 2020-12 | |
dc.identifier.citation | Goh, Jorming, Hofmann, Peter, Aw, Ning Hong, Tan, Poh Ling, Tschakert, Gerhard, Mueller, Alexander, Wong, Siew Cheng, Tan, Frankie, Gan, Linda Seo Hwee (2020-12). Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins (HMGB1, S100A8/A9, HSP70) and inflammatory biomarkers in healthy young men: a pilot study. Translational Medicine Communications 5 (1). ScholarBank@NUS Repository. https://doi.org/10.21203/rs.2.23593/v1 | |
dc.identifier.issn | 2396-832X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/219451 | |
dc.description.abstract | <jats:title>Abstract</jats:title> <jats:p><jats:bold>Background: </jats:bold>Intense exercise is a systemic stressor associated with the release of “danger” molecules – alarmins, by damaged or dying cells into systemic circulation to evoke a sterile inflammatory response. Compared with research in clinical diseases, physiological responses of alarmins to exercise and training are not well studied. Short-term responses to exercise and training using a panel of alarmins – HMGB1, S100A8/A9, HSP70 and sRAGE may reveal unique aspects of stress responses to strenuous exercise with important ramifications when prescribing exercise to generally healthy adults. <jats:bold>Methods: </jats:bold>A 3-week, high-intensity training program was performed by healthy young men (N = 7). Concurrent aerobic and resistance exercises were performed on 3 consecutive days each week. Blood and saliva were collected before (<jats:italic>Pre</jats:italic>), immediately after (<jats:italic>Post</jats:italic>), and 30 min (<jats:italic>30 min</jats:italic>) after exercise each week, and 24 h after the final exercise session in week 3 (<jats:italic>24 h</jats:italic>). <jats:bold>Results: </jats:bold>Plasma HMGB1, S100A8/A9 and HSP70 increased from <jats:italic>Pre</jats:italic> to <jats:italic>Post </jats:italic>(P < 0.05)<jats:italic>,</jats:italic> although at different timepoints during the study, and displayed different kinetics from IL-10, IL-8 and IFN-γ, suggesting unique mechanisms involved in modulating their release and clearance. CD14<jats:sup>+</jats:sup>CD16<jats:sup>-</jats:sup> monocytes increased from <jats:italic>Pre </jats:italic>to <jats:italic>Post </jats:italic>across 3 weeks; CD14<jats:sup>+</jats:sup>CD16<jats:sup>+</jats:sup> monocytes increased from <jats:italic>Pre </jats:italic>to <jats:italic>Post </jats:italic>in<jats:italic> </jats:italic>week 2 and 3 (P < 0.05).<jats:italic> </jats:italic>ΔHMGB1 and ΔHSP70 correlated positively with ΔMCP-1 during 3 weeks of training, while ΔHMGB1 correlated positively with CD14<jats:sup>+</jats:sup>CD16<jats:sup>- </jats:sup>monocytes, suggesting higher alarmin release after strenuous exercise may involve increase in circulating monocytes. <jats:bold>Conclusions: </jats:bold>Perturbations in systemic alarmins are novel biological signatures for assessing the inflammatory milieu of healthy adults during high-intensity exercise.</jats:p> | |
dc.publisher | Springer Science and Business Media LLC | |
dc.source | Elements | |
dc.subject | Exercise | |
dc.subject | Alarmins | |
dc.subject | HMGB1 | |
dc.subject | S100A8/A9 | |
dc.subject | HSP70 | |
dc.subject | sRAGE | |
dc.type | Article | |
dc.date.updated | 2022-04-21T02:06:28Z | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | PAEDIATRICS | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.21203/rs.2.23593/v1 | |
dc.description.sourcetitle | Translational Medicine Communications | |
dc.description.volume | 5 | |
dc.description.issue | 1 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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Goh J et al. Trans Med Commun 2020 - Concurrent high-intensity aerobic and resistance exercise modulates systemic release of alarmins.pdf | 1.91 MB | Adobe PDF | OPEN | None | View/Download |
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