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https://doi.org/10.1111/febs.16337
| Title: | Targeting the molecular & cellular pillars of human aging with exercise | Authors: | Goh, Jorming Wong, Esther Soh, Janjira Maier, Andrea Britta Kennedy, Brian Keith |
Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology aging disruption in proteostasis dysregulated stress response epigenetic drift inflammaging macromolecular damage metabolic dysregulation stem cell exhaustion MUSCLE MITOCHONDRIAL BIOGENESIS CIRCULATING ANGIOGENIC CELLS UNFOLDED PROTEIN RESPONSE MESSENGER-RNA EXPRESSION HEMATOPOIETIC STEM-CELLS CORONARY-HEART-DISEASE RAT SKELETAL-MUSCLE VIGOROUS EXERCISE PHYSICAL-ACTIVITY DNA-DAMAGE |
Issue Date: | 7-Feb-2022 | Publisher: | WILEY | Citation: | Goh, Jorming, Wong, Esther, Soh, Janjira, Maier, Andrea Britta, Kennedy, Brian Keith (2022-02-07). Targeting the molecular & cellular pillars of human aging with exercise. FEBS JOURNAL. ScholarBank@NUS Repository. https://doi.org/10.1111/febs.16337 | Abstract: | Biological aging is the main driver of age-associated chronic diseases. In 2014, the United States National Institute of Aging (NIA) sponsored a meeting between several investigators in the field of aging biology, who identified seven biological pillars of aging and a consensus review, “Geroscience: Linking Aging to Chronic Disease,” was published. The pillars of aging demonstrated the conservation of aging pathways in diverse model organisms and thus represent a useful framework with which to study human aging. In this present review, we revisit the seven pillars of aging from the perspective of exercise and discuss how regular physical exercise can modulate these pillars to stave off age-related chronic diseases and maintain functional capacity. | Source Title: | FEBS JOURNAL | URI: | https://scholarbank.nus.edu.sg/handle/10635/219437 | ISSN: | 1742-464X 1742-4658 |
DOI: | 10.1111/febs.16337 |
| Appears in Collections: | Staff Publications Elements |
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