Please use this identifier to cite or link to this item: https://doi.org/10.3390/molecules26102914
Title: Biosynthesis of Nature-Inspired Unnatural Cannabinoids
Authors: Lim, Kevin JH 
Lim, Yan Ping 
Hartono, Yossa D 
Go, Maybelle K 
Fan, Hao 
Yew, Wen Shan 
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
Cannabis sativa
cannabinoids biosynthesis
metabolic engineering
synthetic enzymology
natural products
cannabinoid receptors
drug design
TETRAHYDROCANNABINOLIC ACID-SYNTHASE
COUPLED RECEPTOR 18
ALLOSTERIC MODULATOR
CRYSTAL-STRUCTURE
STRUCTURAL BASIS
AROMATIC PRENYLTRANSFERASES
TETRACENOMYCIN-F2 CYCLASE
(+/-)-DAURICHROMENIC ACID
CYCLIZATION SPECIFICITY
ENDOCANNABINOID SYSTEM
Issue Date: 1-May-2021
Publisher: MDPI
Citation: Lim, Kevin JH, Lim, Yan Ping, Hartono, Yossa D, Go, Maybelle K, Fan, Hao, Yew, Wen Shan (2021-05-01). Biosynthesis of Nature-Inspired Unnatural Cannabinoids. MOLECULES 26 (10). ScholarBank@NUS Repository. https://doi.org/10.3390/molecules26102914
Abstract: Natural products make up a large proportion of medicine available today. Cannabinoids from the plant Cannabis sativa is one unique class of meroterpenoids that have shown a wide range of bioactivities and recently seen significant developments in their status as therapeutic agents for various indications. Their complex chemical structures make it difficult to chemically synthesize them in efficient yields. Synthetic biology has presented a solution to this through metabolic engineering in heterologous hosts. Through genetic manipulation, rare phytocannabinoids that are produced in low yields in the plant can now be synthesized in larger quantities for therapeutic and commercial use. Additionally, an exciting avenue of exploring new chemical spaces is made available as novel derivatized compounds can be produced and investigated for their bioactivities. In this review, we summarized the biosynthetic pathways of phytocannabinoids and synthetic biology efforts in producing them in heterologous hosts. Detailed mechanistic insights are discussed in each part of the pathway in order to explore strategies for creating novel cannabinoids. Lastly, we discussed studies conducted on biological targets such as CB1, CB2 and orphan receptors along with their affinities to these cannabinoid ligands with a view to inform upstream diversification efforts.
Source Title: MOLECULES
URI: https://scholarbank.nus.edu.sg/handle/10635/218858
ISSN: 14203049
DOI: 10.3390/molecules26102914
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