Please use this identifier to cite or link to this item: https://doi.org/10.3390/molecules26102914
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dc.titleBiosynthesis of Nature-Inspired Unnatural Cannabinoids
dc.contributor.authorLim, Kevin JH
dc.contributor.authorLim, Yan Ping
dc.contributor.authorHartono, Yossa D
dc.contributor.authorGo, Maybelle K
dc.contributor.authorFan, Hao
dc.contributor.authorYew, Wen Shan
dc.date.accessioned2022-04-11T07:10:55Z
dc.date.available2022-04-11T07:10:55Z
dc.date.issued2021-05-01
dc.identifier.citationLim, Kevin JH, Lim, Yan Ping, Hartono, Yossa D, Go, Maybelle K, Fan, Hao, Yew, Wen Shan (2021-05-01). Biosynthesis of Nature-Inspired Unnatural Cannabinoids. MOLECULES 26 (10). ScholarBank@NUS Repository. https://doi.org/10.3390/molecules26102914
dc.identifier.issn14203049
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/218858
dc.description.abstractNatural products make up a large proportion of medicine available today. Cannabinoids from the plant Cannabis sativa is one unique class of meroterpenoids that have shown a wide range of bioactivities and recently seen significant developments in their status as therapeutic agents for various indications. Their complex chemical structures make it difficult to chemically synthesize them in efficient yields. Synthetic biology has presented a solution to this through metabolic engineering in heterologous hosts. Through genetic manipulation, rare phytocannabinoids that are produced in low yields in the plant can now be synthesized in larger quantities for therapeutic and commercial use. Additionally, an exciting avenue of exploring new chemical spaces is made available as novel derivatized compounds can be produced and investigated for their bioactivities. In this review, we summarized the biosynthetic pathways of phytocannabinoids and synthetic biology efforts in producing them in heterologous hosts. Detailed mechanistic insights are discussed in each part of the pathway in order to explore strategies for creating novel cannabinoids. Lastly, we discussed studies conducted on biological targets such as CB1, CB2 and orphan receptors along with their affinities to these cannabinoid ligands with a view to inform upstream diversification efforts.
dc.language.isoen
dc.publisherMDPI
dc.sourceElements
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectPhysical Sciences
dc.subjectBiochemistry & Molecular Biology
dc.subjectChemistry, Multidisciplinary
dc.subjectChemistry
dc.subjectCannabis sativa
dc.subjectcannabinoids biosynthesis
dc.subjectmetabolic engineering
dc.subjectsynthetic enzymology
dc.subjectnatural products
dc.subjectcannabinoid receptors
dc.subjectdrug design
dc.subjectTETRAHYDROCANNABINOLIC ACID-SYNTHASE
dc.subjectCOUPLED RECEPTOR 18
dc.subjectALLOSTERIC MODULATOR
dc.subjectCRYSTAL-STRUCTURE
dc.subjectSTRUCTURAL BASIS
dc.subjectAROMATIC PRENYLTRANSFERASES
dc.subjectTETRACENOMYCIN-F2 CYCLASE
dc.subject(+/-)-DAURICHROMENIC ACID
dc.subjectCYCLIZATION SPECIFICITY
dc.subjectENDOCANNABINOID SYSTEM
dc.typeReview
dc.date.updated2022-04-11T02:57:14Z
dc.contributor.departmentBIOCHEMISTRY
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.3390/molecules26102914
dc.description.sourcetitleMOLECULES
dc.description.volume26
dc.description.issue10
dc.published.statePublished
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