Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41698-019-0087-0
Title: Pan-cancer analysis connects tumor matrisome to immune response
Authors: Lim, Su Bin
Chua, Melvin Lee Kiang 
Yeong, Joe Poh Sheng
Jin, Swee Jin
Lim, Wan-Teck 
Lim, Chwee Teck 
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
BREAST-CANCER
EXTRACELLULAR-MATRIX
EXPRESSION
METASTASIS
BIOMARKERS
BLOCKADE
SURVIVAL
ANTIGEN
TISSUES
SAMPLES
Issue Date: 22-May-2019
Publisher: NATURE PUBLISHING GROUP
Citation: Lim, Su Bin, Chua, Melvin Lee Kiang, Yeong, Joe Poh Sheng, Jin, Swee Jin, Lim, Wan-Teck, Lim, Chwee Teck (2019-05-22). Pan-cancer analysis connects tumor matrisome to immune response. NPJ PRECISION ONCOLOGY 3 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41698-019-0087-0
Abstract: Recent sequencing efforts unveil genomic landscapes of tumor microenvironment. A key compartment in this niche is the extracellular matrix (ECM) and its related components – matrisome. Yet, little is known about the extent to which matrisome pattern is conserved in progressive tumors across diverse cancer types. Using integrative genomic approaches, we conducted multi-platform assessment of a measure of deregulated matrisome associated with tumor progression, termed as tumor matrisome index (TMI), in over 30,000 patient-derived samples. Combined quantitative analyses of genomics and proteomics reveal that TMI is closely associated with mutational load, tumor pathology, and predicts survival across different malignancies. Interestingly, we observed an enrichment of specific tumor-infiltrating immune cell populations, along with signatures predictive of resistance to immune checkpoint blockade immunotherapy, and clinically targetable immune checkpoints in TMIhigh tumors. B7-H3 emerged as a particularly promising target for anti-tumor immunity in these tumors. Here, we show that matrisomal abnormalities could represent a potential clinically useful biomarker for prognostication and prediction of immunotherapy response.
Source Title: NPJ PRECISION ONCOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/218597
ISSN: 2397768X
DOI: 10.1038/s41698-019-0087-0
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