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Title: Adjunctive probiotics after periodontal debridement versus placebo: A systematic review and meta-analysis
Authors: Ethan Ng
John Tay
SE Saffari 
Lum Peng Lim 
Kong Mun Chung 
Marianne Ong
Keywords: Bifidobacterium
periodontal debridement
Issue Date: 1-Jul-2021
Publisher: Taylor & Francis
Citation: Ethan Ng, John Tay, SE Saffari, Lum Peng Lim, Kong Mun Chung, Marianne Ong (2021-07-01). Adjunctive probiotics after periodontal debridement versus placebo: A systematic review and meta-analysis. Acta Odontologica Scandinavica 80 (02) : 81-90. ScholarBank@NUS Repository.
Abstract: Objective: To comprehensively investigate the efficacy of adjunctive probiotics compared to placebo, using conventional and novel treatment outcomes. Materials and methods: Three databases (MEDLINE, EMBASE, and CENTRAL) were searched. Outcomes included percent change in the total number of deep sites before and after therapy, change in mean probing pocket depth (mm), percentage patients requiring additional therapy, risk for disease progression, and microbiological and immunological results. Meta-analysis was conducted to evaluate treatment effects wherever appropriate. Results: Ten studies were selected from 818 records. Meta-analysis showed that adjunctive probiotics had no additional benefit for percentage change of the total number of deeper sites (≥5 mm, ≥6 mm, ≥7 mm) before and after therapy. No significant difference was observed for mean probing pocket depth reduction at 3 and 6 months. Statistically significant beneficial odds ratios for need for additional therapy (OR = 0.19, 95% CI [0.07-0.56]) and risk of disease progression (OR = 0.32, 95% CI [0.14-0.73]) were observed with probiotic administration. Immunological rather than microbiological outcomes correlated more consistently with clinical findings. No adverse events were reported. Conclusions: Adjunctive probiotics are safe in systemically healthy individuals and could offer additional patient-level benefits compared to placebo, hence its use can sometimes be justified.
Source Title: Acta Odontologica Scandinavica
ISSN: 0001-6357
DOI: 10.1080/00016357.2021.1942193
Appears in Collections:Staff Publications

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