Please use this identifier to cite or link to this item: https://doi.org/10.1080/00016357.2021.1942193
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dc.titleAdjunctive probiotics after periodontal debridement versus placebo: A systematic review and meta-analysis
dc.contributor.authorEthan Ng
dc.contributor.authorJohn Tay
dc.contributor.authorSE Saffari
dc.contributor.authorLum Peng Lim
dc.contributor.authorKong Mun Chung
dc.contributor.authorMarianne Ong
dc.date.accessioned2022-03-14T03:22:48Z
dc.date.available2022-03-14T03:22:48Z
dc.date.issued2021-07-01
dc.identifier.citationEthan Ng, John Tay, SE Saffari, Lum Peng Lim, Kong Mun Chung, Marianne Ong (2021-07-01). Adjunctive probiotics after periodontal debridement versus placebo: A systematic review and meta-analysis. Acta Odontologica Scandinavica 80 (02) : 81-90. ScholarBank@NUS Repository. https://doi.org/10.1080/00016357.2021.1942193
dc.identifier.issn0001-6357
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/217036
dc.description.abstractObjective: To comprehensively investigate the efficacy of adjunctive probiotics compared to placebo, using conventional and novel treatment outcomes. Materials and methods: Three databases (MEDLINE, EMBASE, and CENTRAL) were searched. Outcomes included percent change in the total number of deep sites before and after therapy, change in mean probing pocket depth (mm), percentage patients requiring additional therapy, risk for disease progression, and microbiological and immunological results. Meta-analysis was conducted to evaluate treatment effects wherever appropriate. Results: Ten studies were selected from 818 records. Meta-analysis showed that adjunctive probiotics had no additional benefit for percentage change of the total number of deeper sites (≥5 mm, ≥6 mm, ≥7 mm) before and after therapy. No significant difference was observed for mean probing pocket depth reduction at 3 and 6 months. Statistically significant beneficial odds ratios for need for additional therapy (OR = 0.19, 95% CI [0.07-0.56]) and risk of disease progression (OR = 0.32, 95% CI [0.14-0.73]) were observed with probiotic administration. Immunological rather than microbiological outcomes correlated more consistently with clinical findings. No adverse events were reported. Conclusions: Adjunctive probiotics are safe in systemically healthy individuals and could offer additional patient-level benefits compared to placebo, hence its use can sometimes be justified.
dc.publisherTaylor & Francis
dc.sourceTaylor & Francis
dc.subjectBifidobacterium
dc.subjectLactobacillus
dc.subjecthost-modulation
dc.subjectperiodontal debridement
dc.subjectperiodontitis
dc.typeArticle
dc.contributor.departmentDEAN'S OFFICE (DENTISTRY)
dc.contributor.departmentDEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
dc.contributor.departmentDENTISTRY
dc.description.doi10.1080/00016357.2021.1942193
dc.description.sourcetitleActa Odontologica Scandinavica
dc.description.volume80
dc.description.issue02
dc.description.page81-90
dc.published.statePublished
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