Please use this identifier to cite or link to this item: https://doi.org/10.3390/nu13124245
Title: Branched Chain Amino Acid Supplementation to a Hypocaloric Diet Does Not Affect Resting Metabolic Rate but Increases Postprandial Fat Oxidation Response in Overweight and Obese Adults after Weight Loss Intervention
Authors: Ooi, Delicia Shu Qin 
Ling, Jennifer Qiu Rong
Ong, Fang Yi
Tai, E Shyong 
Henry, Christiani Jeyakumar 
Leow, Melvin Khee Shing 
Khoo, Eric Yin Hao 
Tan, Chuen Seng 
Chong, Mary Foong Fong 
Khoo, Chin Meng 
Lee, Yung Seng 
Keywords: Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
branched chain amino acids (BCAA)
resting metabolic rate (RMR)
diet-induced thermogenesis (DIT)
respiratory quotient (RQ)
carbohydrate oxidation
lipid oxidation
hypocaloric diet
high-protein
weight loss
obese and overweight adults
ENERGY-EXPENDITURE
BODY-COMPOSITION
ADAPTIVE THERMOGENESIS
LEAN MASS
PHYSICAL-ACTIVITY
SQUAT EXERCISE
MUSCLE DAMAGE
PROTEIN
GAIN
MEN
Issue Date: 1-Dec-2021
Publisher: MDPI
Citation: Ooi, Delicia Shu Qin, Ling, Jennifer Qiu Rong, Ong, Fang Yi, Tai, E Shyong, Henry, Christiani Jeyakumar, Leow, Melvin Khee Shing, Khoo, Eric Yin Hao, Tan, Chuen Seng, Chong, Mary Foong Fong, Khoo, Chin Meng, Lee, Yung Seng (2021-12-01). Branched Chain Amino Acid Supplementation to a Hypocaloric Diet Does Not Affect Resting Metabolic Rate but Increases Postprandial Fat Oxidation Response in Overweight and Obese Adults after Weight Loss Intervention. NUTRIENTS 13 (12). ScholarBank@NUS Repository. https://doi.org/10.3390/nu13124245
Abstract: Background: Branched chain amino acids (BCAA) supplementation is reported to aid in lean mass preservation, which may in turn minimize the reduction in resting metabolic rate (RMR) during weight loss. Our study aimed to examine the effect of BCAA supplementation to a hypocaloric diet on RMR and substrate utilization during a weight loss intervention. Methods: A total of 111 Chinese subjects comprising 55 males and 56 females aged 21 to 45 years old with BMI between 25 and 36 kg/m2 were randomized into three hypocaloric diet groups: (1) standard-protein (14%) with placebo (CT), (2) standard-protein with BCAA, and (3) high-protein (27%) with placebo. Indirect calorimetry was used to measure RMR, carbohydrate, and fat oxidation before and after 16 weeks of dietary intervention. Results: RMR was reduced from 1600 ± 270 kcal/day to 1500 ± 264 kcal/day (p < 0.0005) after weight loss, but no significant differences in the change of RMR, respiratory quotient, and percentage of fat and carbohydrate oxidation were observed among the three diet groups. Subjects with BCAA supplementation had an increased postprandial fat (p = 0.021) and decreased postprandial carbohydrate (p = 0.044) oxidation responses compared to the CT group after dietary intervention. Conclusions: BCAA-supplemented standard-protein diet did not significantly attenuate reduction of RMR compared to standard-protein and high-protein diets. However, the postprandial fat oxidation response increased after BCAA-supplemented weight loss intervention.
Source Title: NUTRIENTS
URI: https://scholarbank.nus.edu.sg/handle/10635/215617
ISSN: 2072-6643
2072-6643
DOI: 10.3390/nu13124245
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