Please use this identifier to cite or link to this item: https://doi.org/10.4103/1673-5374.327327
Title: The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
Authors: Razar, RBBA
Qu, Y 
Gunaseelan, S 
Chua, JJE 
Keywords: fasciculation and elongation protein zeta-1
neurological disorder
neuronal development
neuronal differentiation
neuronal networks
synapse formation
synaptic function
Issue Date: 1-Jun-2022
Publisher: Medknow
Citation: Razar, RBBA, Qu, Y, Gunaseelan, S, Chua, JJE (2022-06-01). The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders. Neural Regeneration Research 17 (6) : 1165-1171. ScholarBank@NUS Repository. https://doi.org/10.4103/1673-5374.327327
Abstract: The human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain regions. Compelling converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological disorders. Supporting this notion, efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation, maturation, synaptogenesis and synaptic function. Fasciculation and elongation protein zeta-1, a Kinesin-1 adapter, has emerged as a key central player involved in many of these processes. Fasciculation and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse establishment. Furthermore, it acts downstream of guidance cue pathways to regulate axo-dendritic development. Significantly, perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous system. Mutations and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental disorders. Moreover, altered phosphorylation of the protein contributes to neurodegenerative disorders. Together, these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.
Source Title: Neural Regeneration Research
URI: https://scholarbank.nus.edu.sg/handle/10635/215537
ISSN: 16735374
18767958
DOI: 10.4103/1673-5374.327327
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