Please use this identifier to cite or link to this item: https://doi.org/10.4103/1673-5374.327327
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dc.titleThe importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders
dc.contributor.authorRazar, RBBA
dc.contributor.authorQu, Y
dc.contributor.authorGunaseelan, S
dc.contributor.authorChua, JJE
dc.date.accessioned2022-02-18T04:31:47Z
dc.date.available2022-02-18T04:31:47Z
dc.date.issued2022-06-01
dc.identifier.citationRazar, RBBA, Qu, Y, Gunaseelan, S, Chua, JJE (2022-06-01). The importance of fasciculation and elongation protein zeta-1 in neural circuit establishment and neurological disorders. Neural Regeneration Research 17 (6) : 1165-1171. ScholarBank@NUS Repository. https://doi.org/10.4103/1673-5374.327327
dc.identifier.issn16735374
dc.identifier.issn18767958
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/215537
dc.description.abstractThe human brain contains an estimated 100 billion neurons that must be systematically organized into functional neural circuits for it to function properly. These circuits range from short-range local signaling networks between neighboring neurons to long-range networks formed between various brain regions. Compelling converging evidence indicates that alterations in neural circuits arising from abnormalities during early neuronal development or neurodegeneration contribute significantly to the etiology of neurological disorders. Supporting this notion, efforts to identify genetic causes of these disorders have uncovered an over-representation of genes encoding proteins involved in the processes of neuronal differentiation, maturation, synaptogenesis and synaptic function. Fasciculation and elongation protein zeta-1, a Kinesin-1 adapter, has emerged as a key central player involved in many of these processes. Fasciculation and elongation protein zeta-1-dependent transport of synaptic cargoes and mitochondria is essential for neuronal development and synapse establishment. Furthermore, it acts downstream of guidance cue pathways to regulate axo-dendritic development. Significantly, perturbing its function causes abnormalities in neuronal development and synapse formation both in the brain as well as the peripheral nervous system. Mutations and deletions of the fasciculation and elongation protein zeta-1 gene are linked to neurodevelopmental disorders. Moreover, altered phosphorylation of the protein contributes to neurodegenerative disorders. Together, these findings strongly implicate the importance of fasciculation and elongation protein zeta-1 in the establishment of neuronal circuits and its maintenance.
dc.publisherMedknow
dc.sourceElements
dc.subjectfasciculation and elongation protein zeta-1
dc.subjectneurological disorder
dc.subjectneuronal development
dc.subjectneuronal differentiation
dc.subjectneuronal networks
dc.subjectsynapse formation
dc.subjectsynaptic function
dc.typeReview
dc.date.updated2022-02-18T04:23:19Z
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.4103/1673-5374.327327
dc.description.sourcetitleNeural Regeneration Research
dc.description.volume17
dc.description.issue6
dc.description.page1165-1171
dc.published.stateUnpublished
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