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https://doi.org/10.1016/j.ebiom.2018.11.053
Title: | Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence | Authors: | Xu, W. Monaco, G. Wong, E.H. Tan, W.L.W. Kared, H. Simoni, Y. Tan, S.W. How, W.Z.Y. Tan, C.T.Y. Lee, B.T.K. Carbajo, D. Srinivasan, K.G. Low, I.C.H. Mok, E.W.H. Foo, S. Lum, J. Tey, H.L. Tan, W.P. Poidinger, M. Newell, E. Ng, T.P. Foo, R. Akbar, A.N. Fülöp, T. Larbi, A. |
Keywords: | Aging Cellular Senescence Gamma Delta T cells Immunobiology Immunosenescence Innate Immunity |
Issue Date: | 2019 | Publisher: | Elsevier B.V. | Citation: | Xu, W., Monaco, G., Wong, E.H., Tan, W.L.W., Kared, H., Simoni, Y., Tan, S.W., How, W.Z.Y., Tan, C.T.Y., Lee, B.T.K., Carbajo, D., Srinivasan, K.G., Low, I.C.H., Mok, E.W.H., Foo, S., Lum, J., Tey, H.L., Tan, W.P., Poidinger, M., Newell, E., Ng, T.P., Foo, R., Akbar, A.N., Fülöp, T., Larbi, A. (2019). Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence. EBioMedicine 39 : 44-58. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ebiom.2018.11.053 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International | Abstract: | Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T cell subsets phenotypes, functions, senescence and their molecular response to stress. Methods: Peripheral blood of young and old donors in Singapore have been used to assess the phenotype, functional capacity, proliferation capacity and gene expression of the various γδ T cell subsets. Peripheral blood mononuclear cells from apheresis cones and young donors have been used to characterize the telomere length, epigenetics profile and DNA damage response of the various γδ T cell subsets phenotype. Findings: Our data shows that peripheral Vδ2+ phenotype, functional capacity (cytokines, cytotoxicity, proliferation) and gene expression profile are specific when compared against all other αβ and γδ T cells in aging. Hallmarks of senescence including telomere length, epigenetic profile and DNA damage response of Vδ2+ also differs against all other αβ and γδ T cells. Interpretation: Our results highlight the differential impact of lifelong stress on γδ T cells subsets, and highlight possible mechanisms that enable Vδ2+ to be resistant to cellular aging. The new findings reinforce the concept that Vδ2+ have an "innate-like" behavior and are more resilient to the environment as compared to "adaptive-like" Vδ1+ T cells. © 2018 The Authors | Source Title: | EBioMedicine | URI: | https://scholarbank.nus.edu.sg/handle/10635/213747 | ISSN: | 2352-3964 | DOI: | 10.1016/j.ebiom.2018.11.053 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International |
Appears in Collections: | Staff Publications Elements |
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