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Title: Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence
Authors: Xu, W.
Monaco, G.
Wong, E.H.
Tan, W.L.W.
Kared, H.
Simoni, Y.
Tan, S.W.
How, W.Z.Y.
Tan, C.T.Y.
Lee, B.T.K.
Carbajo, D.
Srinivasan, K.G.
Low, I.C.H.
Mok, E.W.H.
Foo, S.
Lum, J.
Tey, H.L.
Tan, W.P.
Poidinger, M.
Newell, E.
Ng, T.P. 
Foo, R.
Akbar, A.N.
Fülöp, T.
Larbi, A. 
Keywords: Aging
Cellular Senescence
Gamma Delta T cells
Innate Immunity
Issue Date: 2019
Publisher: Elsevier B.V.
Citation: Xu, W., Monaco, G., Wong, E.H., Tan, W.L.W., Kared, H., Simoni, Y., Tan, S.W., How, W.Z.Y., Tan, C.T.Y., Lee, B.T.K., Carbajo, D., Srinivasan, K.G., Low, I.C.H., Mok, E.W.H., Foo, S., Lum, J., Tey, H.L., Tan, W.P., Poidinger, M., Newell, E., Ng, T.P., Foo, R., Akbar, A.N., Fülöp, T., Larbi, A. (2019). Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence. EBioMedicine 39 : 44-58. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T cell subsets phenotypes, functions, senescence and their molecular response to stress. Methods: Peripheral blood of young and old donors in Singapore have been used to assess the phenotype, functional capacity, proliferation capacity and gene expression of the various γδ T cell subsets. Peripheral blood mononuclear cells from apheresis cones and young donors have been used to characterize the telomere length, epigenetics profile and DNA damage response of the various γδ T cell subsets phenotype. Findings: Our data shows that peripheral Vδ2+ phenotype, functional capacity (cytokines, cytotoxicity, proliferation) and gene expression profile are specific when compared against all other αβ and γδ T cells in aging. Hallmarks of senescence including telomere length, epigenetic profile and DNA damage response of Vδ2+ also differs against all other αβ and γδ T cells. Interpretation: Our results highlight the differential impact of lifelong stress on γδ T cells subsets, and highlight possible mechanisms that enable Vδ2+ to be resistant to cellular aging. The new findings reinforce the concept that Vδ2+ have an "innate-like" behavior and are more resilient to the environment as compared to "adaptive-like" Vδ1+ T cells. © 2018 The Authors
Source Title: EBioMedicine
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2018.11.053
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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