Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.ebiom.2018.11.053
DC Field | Value | |
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dc.title | Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence | |
dc.contributor.author | Xu, W. | |
dc.contributor.author | Monaco, G. | |
dc.contributor.author | Wong, E.H. | |
dc.contributor.author | Tan, W.L.W. | |
dc.contributor.author | Kared, H. | |
dc.contributor.author | Simoni, Y. | |
dc.contributor.author | Tan, S.W. | |
dc.contributor.author | How, W.Z.Y. | |
dc.contributor.author | Tan, C.T.Y. | |
dc.contributor.author | Lee, B.T.K. | |
dc.contributor.author | Carbajo, D. | |
dc.contributor.author | Srinivasan, K.G. | |
dc.contributor.author | Low, I.C.H. | |
dc.contributor.author | Mok, E.W.H. | |
dc.contributor.author | Foo, S. | |
dc.contributor.author | Lum, J. | |
dc.contributor.author | Tey, H.L. | |
dc.contributor.author | Tan, W.P. | |
dc.contributor.author | Poidinger, M. | |
dc.contributor.author | Newell, E. | |
dc.contributor.author | Ng, T.P. | |
dc.contributor.author | Foo, R. | |
dc.contributor.author | Akbar, A.N. | |
dc.contributor.author | Fülöp, T. | |
dc.contributor.author | Larbi, A. | |
dc.date.accessioned | 2022-01-11T06:20:58Z | |
dc.date.available | 2022-01-11T06:20:58Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Xu, W., Monaco, G., Wong, E.H., Tan, W.L.W., Kared, H., Simoni, Y., Tan, S.W., How, W.Z.Y., Tan, C.T.Y., Lee, B.T.K., Carbajo, D., Srinivasan, K.G., Low, I.C.H., Mok, E.W.H., Foo, S., Lum, J., Tey, H.L., Tan, W.P., Poidinger, M., Newell, E., Ng, T.P., Foo, R., Akbar, A.N., Fülöp, T., Larbi, A. (2019). Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence. EBioMedicine 39 : 44-58. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ebiom.2018.11.053 | |
dc.identifier.issn | 2352-3964 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/213747 | |
dc.description.abstract | Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T cell subsets phenotypes, functions, senescence and their molecular response to stress. Methods: Peripheral blood of young and old donors in Singapore have been used to assess the phenotype, functional capacity, proliferation capacity and gene expression of the various γδ T cell subsets. Peripheral blood mononuclear cells from apheresis cones and young donors have been used to characterize the telomere length, epigenetics profile and DNA damage response of the various γδ T cell subsets phenotype. Findings: Our data shows that peripheral Vδ2+ phenotype, functional capacity (cytokines, cytotoxicity, proliferation) and gene expression profile are specific when compared against all other αβ and γδ T cells in aging. Hallmarks of senescence including telomere length, epigenetic profile and DNA damage response of Vδ2+ also differs against all other αβ and γδ T cells. Interpretation: Our results highlight the differential impact of lifelong stress on γδ T cells subsets, and highlight possible mechanisms that enable Vδ2+ to be resistant to cellular aging. The new findings reinforce the concept that Vδ2+ have an "innate-like" behavior and are more resilient to the environment as compared to "adaptive-like" Vδ1+ T cells. © 2018 The Authors | |
dc.publisher | Elsevier B.V. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Scopus OA2019 | |
dc.subject | Aging | |
dc.subject | Cellular Senescence | |
dc.subject | Gamma Delta T cells | |
dc.subject | Immunobiology | |
dc.subject | Immunosenescence | |
dc.subject | Innate Immunity | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | PSYCHOLOGICAL MEDICINE | |
dc.description.doi | 10.1016/j.ebiom.2018.11.053 | |
dc.description.sourcetitle | EBioMedicine | |
dc.description.volume | 39 | |
dc.description.page | 44-58 | |
dc.published.state | Unpublished | |
Appears in Collections: | Staff Publications Elements |
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