Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-019-10443-2
Title: Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
Authors: Dorajoo, R.
Chang, X. 
Gurung, R.L.
Li, Z.
Wang, L.
Wang, R.
Beckman, K.B.
Adams-Haduch, J.
M, Y.
Liu, S.
Meah, W.Y.
Sim, K.S.
Lim, S.C. 
Friedlander, Y.
Liu, J. 
van Dam, R.M. 
Yuan, J.-M.
Koh, W.-P. 
Khor, C.C.
Heng, C.-K. 
Issue Date: 2019
Publisher: Nature Publishing Group
Citation: Dorajoo, R., Chang, X., Gurung, R.L., Li, Z., Wang, L., Wang, R., Beckman, K.B., Adams-Haduch, J., M, Y., Liu, S., Meah, W.Y., Sim, K.S., Lim, S.C., Friedlander, Y., Liu, J., van Dam, R.M., Yuan, J.-M., Koh, W.-P., Khor, C.C., Heng, C.-K. (2019). Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies. Nature Communications 10 (1) : 2491. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-10443-2
Rights: Attribution 4.0 International
Abstract: Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of 23,096 Singaporean Chinese samples identifies 10 genome-wide loci (P < 5 × 10?8). Several of these contain candidate genes (TINF2, PARP1, TERF1, ATM and POT1) with potential roles in telomere biology and DNA repair mechanisms. Meta-analyses with additional 37,505 European individuals reveals six more genome-wide loci, including associations at MPHOSPH6, NKX2-3 and TYMS. We demonstrate that longer LTL associates with protection against respiratory disease mortality [HR = 0.854(0.804–0.906), P = 1.88 × 10?7] in the Singaporean Chinese samples. We further show that the LTL reducing SNP rs7253490 associates with respiratory infections (P = 7.44 × 10?4) although this effect may not be strongly mediated through LTL. Our data expands on the genetic basis of LTL and may indicate on a potential role of LTL in immune competence. © 2019, The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/213245
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10443-2
Rights: Attribution 4.0 International
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