Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-019-10443-2
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dc.titleLoci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
dc.contributor.authorDorajoo, R.
dc.contributor.authorChang, X.
dc.contributor.authorGurung, R.L.
dc.contributor.authorLi, Z.
dc.contributor.authorWang, L.
dc.contributor.authorWang, R.
dc.contributor.authorBeckman, K.B.
dc.contributor.authorAdams-Haduch, J.
dc.contributor.authorM, Y.
dc.contributor.authorLiu, S.
dc.contributor.authorMeah, W.Y.
dc.contributor.authorSim, K.S.
dc.contributor.authorLim, S.C.
dc.contributor.authorFriedlander, Y.
dc.contributor.authorLiu, J.
dc.contributor.authorvan Dam, R.M.
dc.contributor.authorYuan, J.-M.
dc.contributor.authorKoh, W.-P.
dc.contributor.authorKhor, C.C.
dc.contributor.authorHeng, C.-K.
dc.date.accessioned2022-01-07T03:50:11Z
dc.date.available2022-01-07T03:50:11Z
dc.date.issued2019
dc.identifier.citationDorajoo, R., Chang, X., Gurung, R.L., Li, Z., Wang, L., Wang, R., Beckman, K.B., Adams-Haduch, J., M, Y., Liu, S., Meah, W.Y., Sim, K.S., Lim, S.C., Friedlander, Y., Liu, J., van Dam, R.M., Yuan, J.-M., Koh, W.-P., Khor, C.C., Heng, C.-K. (2019). Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies. Nature Communications 10 (1) : 2491. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-019-10443-2
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/213245
dc.description.abstractGenetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of 23,096 Singaporean Chinese samples identifies 10 genome-wide loci (P < 5 × 10?8). Several of these contain candidate genes (TINF2, PARP1, TERF1, ATM and POT1) with potential roles in telomere biology and DNA repair mechanisms. Meta-analyses with additional 37,505 European individuals reveals six more genome-wide loci, including associations at MPHOSPH6, NKX2-3 and TYMS. We demonstrate that longer LTL associates with protection against respiratory disease mortality [HR = 0.854(0.804–0.906), P = 1.88 × 10?7] in the Singaporean Chinese samples. We further show that the LTL reducing SNP rs7253490 associates with respiratory infections (P = 7.44 × 10?4) although this effect may not be strongly mediated through LTL. Our data expands on the genetic basis of LTL and may indicate on a potential role of LTL in immune competence. © 2019, The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.typeArticle
dc.contributor.departmentDEPT OF PAEDIATRICS
dc.contributor.departmentGENOME INSTITUTE OF SINGAPORE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41467-019-10443-2
dc.description.sourcetitleNature Communications
dc.description.volume10
dc.description.issue1
dc.description.page2491
dc.published.statePublished
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