Please use this identifier to cite or link to this item:
DC FieldValue
dc.titleLoci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
dc.contributor.authorDorajoo, R.
dc.contributor.authorChang, X.
dc.contributor.authorGurung, R.L.
dc.contributor.authorLi, Z.
dc.contributor.authorWang, L.
dc.contributor.authorWang, R.
dc.contributor.authorBeckman, K.B.
dc.contributor.authorAdams-Haduch, J.
dc.contributor.authorM, Y.
dc.contributor.authorLiu, S.
dc.contributor.authorMeah, W.Y.
dc.contributor.authorSim, K.S.
dc.contributor.authorLim, S.C.
dc.contributor.authorFriedlander, Y.
dc.contributor.authorLiu, J.
dc.contributor.authorvan Dam, R.M.
dc.contributor.authorYuan, J.-M.
dc.contributor.authorKoh, W.-P.
dc.contributor.authorKhor, C.C.
dc.contributor.authorHeng, C.-K.
dc.identifier.citationDorajoo, R., Chang, X., Gurung, R.L., Li, Z., Wang, L., Wang, R., Beckman, K.B., Adams-Haduch, J., M, Y., Liu, S., Meah, W.Y., Sim, K.S., Lim, S.C., Friedlander, Y., Liu, J., van Dam, R.M., Yuan, J.-M., Koh, W.-P., Khor, C.C., Heng, C.-K. (2019). Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies. Nature Communications 10 (1) : 2491. ScholarBank@NUS Repository.
dc.description.abstractGenetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of 23,096 Singaporean Chinese samples identifies 10 genome-wide loci (P < 5 × 10?8). Several of these contain candidate genes (TINF2, PARP1, TERF1, ATM and POT1) with potential roles in telomere biology and DNA repair mechanisms. Meta-analyses with additional 37,505 European individuals reveals six more genome-wide loci, including associations at MPHOSPH6, NKX2-3 and TYMS. We demonstrate that longer LTL associates with protection against respiratory disease mortality [HR = 0.854(0.804–0.906), P = 1.88 × 10?7] in the Singaporean Chinese samples. We further show that the LTL reducing SNP rs7253490 associates with respiratory infections (P = 7.44 × 10?4) although this effect may not be strongly mediated through LTL. Our data expands on the genetic basis of LTL and may indicate on a potential role of LTL in immune competence. © 2019, The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.sourceScopus OA2019
dc.contributor.departmentDEPT OF PAEDIATRICS
dc.contributor.departmentGENOME INSTITUTE OF SINGAPORE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.sourcetitleNature Communications
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_s41467-019-10443-2.pdf1.57 MBAdobe PDF




checked on Nov 25, 2022

Page view(s)

checked on Nov 17, 2022

Google ScholarTM



This item is licensed under a Creative Commons License Creative Commons