Please use this identifier to cite or link to this item: https://doi.org/10.1088/2515-7639/ab1207
Title: A functional apatite with antibacterial efficacy for bone tissue infections
Authors: Lim, P.N. 
Tong, S.Y. 
Ho, B. 
Wang, W. 
Thian, E.S. 
Keywords: Antibacterial
Apatite
Bone tissue infections
Silicon
Silver
Issue Date: 2019
Publisher: IOP Publishing Ltd
Citation: Lim, P.N., Tong, S.Y., Ho, B., Wang, W., Thian, E.S. (2019). A functional apatite with antibacterial efficacy for bone tissue infections. JPhys Materials 2 (3) : 34004. ScholarBank@NUS Repository. https://doi.org/10.1088/2515-7639/ab1207
Rights: Attribution 4.0 International
Abstract: Silver, silicon co-substituted hydroxyapatite (Ag, Si-HA) was developed to provide bone repair coupled with antibacterial effect, with the aim to address the problems arise in the treatment of bone tissue infections. In this study, Ag, Si-HA demonstrated substantially reduced attachment of Staphylococcus aureus, Propionibacterium acnes, Escherichia coli, and Pseudomonas aeruginosa as compared to HA at 12 h. Being a prolific opportunistic pathogen in bone tissue infections, we investigated if P. aeruginosa could develop resistance against Ag, Si-HA. Our study showed that despite repeated exposure to fresh population of P. aeruginosa every 48 h, Ag, Si-HA exhibited effective antibacterial properties against the growth of P. aeruginosa over 168 h, indicating low risk of inducing bacterial resistance against Ag, Si-HA. As P. aeruginosa produces exotoxins and harbours endotoxins on its cell call, together these toxins could delay healing process. We therefore examined if the effect of these toxins released by P. aeruginosa during the antibacterial assessment on the attachment of mesenchymal stem cells on HA and Ag, Si-HA. Unlike HA, cell attachment on Ag, Si-HA was not affected by the addition of supernatant obtained from the antibacterial assessment of HA and Ag, Si-HA. This demonstrated that Ag, Si-HA could inhibit the growth of bacteria as well as minimise or prevent the detrimental effect from bacteria toxins. � 2019 The Author(s). Published by IOP Publishing Ltd
Source Title: JPhys Materials
URI: https://scholarbank.nus.edu.sg/handle/10635/212953
ISSN: 25157639
DOI: 10.1088/2515-7639/ab1207
Rights: Attribution 4.0 International
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