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Title: Syntaxin 16's Newly Deciphered Roles in Autophagy
Authors: Tang, B.L. 
Keywords: ATG9
syntaxin 16
syntaxin 17
Issue Date: 2019
Publisher: NLM (Medline)
Citation: Tang, B.L. (2019). Syntaxin 16's Newly Deciphered Roles in Autophagy. Cells 8 (12). ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Syntaxin 16, a Qa-SNARE (soluble N-ethylmaleimide-sensitive factor activating protein receptor), is involved in a number of membrane-trafficking activities, particularly transport processes at the trans-Golgi network (TGN). Recent works have now implicated syntaxin 16 in the autophagy process. In fact, syntaxin 16 appears to have dual roles, firstly in facilitating the transport of ATG9a-containing vesicles to growing autophagosomes, and secondly in autolysosome formation. The former involves a putative SNARE complex between syntaxin 16, VAMP7 and SNAP-47. The latter occurs via syntaxin 16's recruitment by Atg8/LC3/GABARAP family proteins to autophagosomes and endo-lysosomes, where syntaxin 16 may act in a manner that bears functional redundancy with the canonical autophagosome Qa-SNARE syntaxin 17. Here, I discuss these recent findings and speculate on the mechanistic aspects of syntaxin 16's newly found role in autophagy.
Source Title: Cells
ISSN: 20734409
DOI: 10.3390/cells8121655
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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