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https://doi.org/10.3390/cells8121655
Title: | Syntaxin 16's Newly Deciphered Roles in Autophagy | Authors: | Tang, B.L. | Keywords: | ATG9 autophagosome autophagy SNARE syntaxin 16 syntaxin 17 VAMP7 |
Issue Date: | 2019 | Publisher: | NLM (Medline) | Citation: | Tang, B.L. (2019). Syntaxin 16's Newly Deciphered Roles in Autophagy. Cells 8 (12). ScholarBank@NUS Repository. https://doi.org/10.3390/cells8121655 | Rights: | Attribution 4.0 International | Abstract: | Syntaxin 16, a Qa-SNARE (soluble N-ethylmaleimide-sensitive factor activating protein receptor), is involved in a number of membrane-trafficking activities, particularly transport processes at the trans-Golgi network (TGN). Recent works have now implicated syntaxin 16 in the autophagy process. In fact, syntaxin 16 appears to have dual roles, firstly in facilitating the transport of ATG9a-containing vesicles to growing autophagosomes, and secondly in autolysosome formation. The former involves a putative SNARE complex between syntaxin 16, VAMP7 and SNAP-47. The latter occurs via syntaxin 16's recruitment by Atg8/LC3/GABARAP family proteins to autophagosomes and endo-lysosomes, where syntaxin 16 may act in a manner that bears functional redundancy with the canonical autophagosome Qa-SNARE syntaxin 17. Here, I discuss these recent findings and speculate on the mechanistic aspects of syntaxin 16's newly found role in autophagy. | Source Title: | Cells | URI: | https://scholarbank.nus.edu.sg/handle/10635/212217 | ISSN: | 20734409 | DOI: | 10.3390/cells8121655 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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