Please use this identifier to cite or link to this item: https://doi.org/10.3390/cells8121655
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dc.titleSyntaxin 16's Newly Deciphered Roles in Autophagy
dc.contributor.authorTang, B.L.
dc.date.accessioned2021-12-29T04:03:49Z
dc.date.available2021-12-29T04:03:49Z
dc.date.issued2019
dc.identifier.citationTang, B.L. (2019). Syntaxin 16's Newly Deciphered Roles in Autophagy. Cells 8 (12). ScholarBank@NUS Repository. https://doi.org/10.3390/cells8121655
dc.identifier.issn20734409
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/212217
dc.description.abstractSyntaxin 16, a Qa-SNARE (soluble N-ethylmaleimide-sensitive factor activating protein receptor), is involved in a number of membrane-trafficking activities, particularly transport processes at the trans-Golgi network (TGN). Recent works have now implicated syntaxin 16 in the autophagy process. In fact, syntaxin 16 appears to have dual roles, firstly in facilitating the transport of ATG9a-containing vesicles to growing autophagosomes, and secondly in autolysosome formation. The former involves a putative SNARE complex between syntaxin 16, VAMP7 and SNAP-47. The latter occurs via syntaxin 16's recruitment by Atg8/LC3/GABARAP family proteins to autophagosomes and endo-lysosomes, where syntaxin 16 may act in a manner that bears functional redundancy with the canonical autophagosome Qa-SNARE syntaxin 17. Here, I discuss these recent findings and speculate on the mechanistic aspects of syntaxin 16's newly found role in autophagy.
dc.publisherNLM (Medline)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2019
dc.subjectATG9
dc.subjectautophagosome
dc.subjectautophagy
dc.subjectSNARE
dc.subjectsyntaxin 16
dc.subjectsyntaxin 17
dc.subjectVAMP7
dc.typeReview
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.3390/cells8121655
dc.description.sourcetitleCells
dc.description.volume8
dc.description.issue12
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