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Title: The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study
Authors: Weaver, N.A.
Zhao, L.
Biesbroek, J.M.
Kuijf, H.J.
Aben, H.P.
Bae, H.-J.
Caballero, M.Á.A.
Chappell, F.M.
Chen, C.P.L.H. 
Dichgans, M.
Duering, M.
Georgakis, M.K.
van der Giessen, R.S.
Gyanwali, B. 
Hamilton, O.K.L.
Hilal, S. 
vom Hofe, E.M.
de Kort, P.L.M.
Koudstaal, P.J.
Lam, B.Y.K.
Lim, J.-S.
Makin, S.D.J.
Mok, V.C.T.
Shi, L.
Valdés Hernández, M.C.
Venketasubramanian, N.
Wardlaw, J.M.
Wollenweber, F.A.
Wong, A.
Xin, X. 
DeCarli, C..
Fletcher, E.A..
Maillard, P..
Barnes, J..
Sudre, C.H..
Schott, J.M..
Ikram, M.A..
Papma, J.M..
Steketee, R.M.E..
Vernooij, M.W..
Bordet, R..
Lopes, R..
Huang, C.-W..
Frayne, R..
McCreary, C.R..
Smith, E.E..
Backes, W..
Köhler, S..
van Oostenbrugge, R.J..
Staals, J..
Verhey, F..
Cheng, C.Y..
Kalaria, R.N..
Werring, D..
Hsu, J.L..
Huang, K.-L..
van der Grond, J..
Jukema, J.W..
van der Mast, R.C..
Nijboer, T.C.W..
Yu, K.-H..
Schmidt, R..
Pirpamer, L..
MacIntosh, B.J..
Robertson, A.D..
de Leeuw, F.-E..
Tuladhar, A.M..
Chaturvedi, N..
Tillin, T..
Brodaty, H..
Sachdev, P..
Barkhof, F..
van der Flier, W.M..
Kappelle, L.J..
Biessels, G.J.
Calgary Normative Study group.
Framingham Heart Study group.
The Dutch Parelsnoer Institute - Neurodegenerative diseases group.
TABASCO group.
Keywords: Cerebrovascular disease
Data harmonization
Lesion location
Lesion-symptom mapping
Small vessel disease
Support vector regression
Vascular cognitive impairment
Issue Date: 2019
Publisher: Elsevier Inc
Citation: Weaver, N.A., Zhao, L., Biesbroek, J.M., Kuijf, H.J., Aben, H.P., Bae, H.-J., Caballero, M.Á.A., Chappell, F.M., Chen, C.P.L.H., Dichgans, M., Duering, M., Georgakis, M.K., van der Giessen, R.S., Gyanwali, B., Hamilton, O.K.L., Hilal, S., vom Hofe, E.M., de Kort, P.L.M., Koudstaal, P.J., Lam, B.Y.K., Lim, J.-S., Makin, S.D.J., Mok, V.C.T., Shi, L., Valdés Hernández, M.C., Venketasubramanian, N., Wardlaw, J.M., Wollenweber, F.A., Wong, A., Xin, X., DeCarli, C.., Fletcher, E.A.., Maillard, P.., Barnes, J.., Sudre, C.H.., Schott, J.M.., Ikram, M.A.., Papma, J.M.., Steketee, R.M.E.., Vernooij, M.W.., Bordet, R.., Lopes, R.., Huang, C.-W.., Frayne, R.., McCreary, C.R.., Smith, E.E.., Backes, W.., Köhler, S.., van Oostenbrugge, R.J.., Staals, J.., Verhey, F.., Cheng, C.Y.., Kalaria, R.N.., Werring, D.., Hsu, J.L.., Huang, K.-L.., van der Grond, J.., Jukema, J.W.., van der Mast, R.C.., Nijboer, T.C.W.., Yu, K.-H.., Schmidt, R.., Pirpamer, L.., MacIntosh, B.J.., Robertson, A.D.., de Leeuw, F.-E.., Tuladhar, A.M.., Chaturvedi, N.., Tillin, T.., Brodaty, H.., Sachdev, P.., Barkhof, F.., van der Flier, W.M.., Kappelle, L.J.., Biessels, G.J., Calgary Normative Study group., Framingham Heart Study group., The Dutch Parelsnoer Institute - Neurodegenerative diseases group., TABASCO group. (2019). The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 11 : 310-326. ScholarBank@NUS Repository.
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
Abstract: Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join. © 2019 The Authors
Source Title: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
ISSN: 23528729
DOI: 10.1016/j.dadm.2019.02.007
Rights: Attribution-NonCommercial-NoDerivatives 4.0 International
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