Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0213615
Title: Factors associated with false-positive mammography at first screen in an Asian population
Authors: Ho, Peh Joo
Bok, Chek Mei
Ishak, Hanis Mariyah Mohd
Lim, Li Yan
Liu, Jenny 
Wong, Fuh Yong 
Chia, Kee Seng 
Tan, Min-Han
Chay, Wen Yee 
Hartman, Mikael 
Li, Jingmei 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
HORMONE REPLACEMENT THERAPY
BREAST-CANCER
DIGITAL MAMMOGRAPHY
PSYCHOSOCIAL CONSEQUENCES
RE-ATTENDANCE
RECALL RATE
WOMEN
RISK
PREVALENCE
PREDICTORS
Issue Date: 11-Mar-2019
Publisher: PUBLIC LIBRARY SCIENCE
Citation: Ho, Peh Joo, Bok, Chek Mei, Ishak, Hanis Mariyah Mohd, Lim, Li Yan, Liu, Jenny, Wong, Fuh Yong, Chia, Kee Seng, Tan, Min-Han, Chay, Wen Yee, Hartman, Mikael, Li, Jingmei (2019-03-11). Factors associated with false-positive mammography at first screen in an Asian population. PLOS ONE 14 (3). ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0213615
Abstract: Introduction False-positive recall is an issue in national screening programmes. The aim of this study is to investigate the recall rate at first screen and to identify potential predictors of false-positive recall in a multi-ethnic Asian population-based breast cancer screening programme. Methods Women aged 50–64 years attending screening mammography for the first time (n = 25,318) were included in this study. The associations between potential predictors (sociodemo-graphic, lifestyle and reproductive) and false-positive recall were evaluated using multivariable logistic regression models. Results The recall rate was 7.6% (n = 1,923), of which with 93.8% were false-positive. Factors independently associated with higher false-positive recall included Indian ethnicity (odds ratio [95% confidence interval]: 1.52 [1.25 to 1.84]), premenopause (1.23 [1.04 to 1.44]), nulliparity (1.85 [1.57 to 2.17]), recent breast symptoms (1.72 [1.31 to 2.23]) and history of breast lump excision (1.87 [1.53 to 2.26]). Factors associated with lower risk of false-positive recall included older age at screen (0.84 [0.73 to 0.97]) and use of oral contraceptives (0.87 [0.78 to 0.97]). After further adjustment of percent mammographic density, associations with older age at screening (0.97 [0.84 to 1.11]) and menopausal status (1.12 [0.95 to 1.32]) were attenuated and no longer significant. Conclusion For every breast cancer identified, 15 women without cancer were subjected to further testing. Efforts to educate Asian women on what it means to be recalled will be useful in reducing unnecessary stress and anxiety.
Source Title: PLOS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/208268
ISSN: 19326203
DOI: 10.1371/journal.pone.0213615
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