Please use this identifier to cite or link to this item: https://doi.org/10.18632/aging.203142
Title: Subclinical vasculopathy and skeletal muscle metrics in the singapore longitudinal ageing study
Authors: Lim, SL 
Liu, X
Gao, Q
Nyunt, SZ 
Gong, L 
Lunaria, JB 
Lam, CSP 
Richards, AM 
Wee, SL 
Ling, LH 
Ng, TP 
Keywords: aortic stiffness
carotid stiffness
endothelial function
muscle function
muscle mass
Aged
Aging
Female
Humans
Linear Models
Longitudinal Studies
Male
Middle Aged
Multivariate Analysis
Muscle, Skeletal
Singapore
Vascular Diseases
Issue Date: 15-Jun-2021
Publisher: Impact Journals, LLC
Citation: Lim, SL, Liu, X, Gao, Q, Nyunt, SZ, Gong, L, Lunaria, JB, Lam, CSP, Richards, AM, Wee, SL, Ling, LH, Ng, TP (2021-06-15). Subclinical vasculopathy and skeletal muscle metrics in the singapore longitudinal ageing study. Aging 13 (11) : 14768-14784. ScholarBank@NUS Repository. https://doi.org/10.18632/aging.203142
Abstract: Frailty is associated with future cardiovascular events in older adults. This cross-sectional study examined the relationship between subclinical vasculopathy with measures of skeletal muscle mass and function. Asymptomatic community-dwelling Asians ≥55 years underwent assessments for subclinical vasculopathy (carotid intima-media thickness (cIMT), aortic and carotid stiffness, and endothelial function), muscle mass (calf circumference adjusted for body mass index) and function (knee extension strength, 6-meter fast gait speed). Multivariable regression analyses for associates of muscle mass/function controlled for demographics and cardiometabolic risk factors. Among 336 participants (median age 62 years, 55.1% male, 3.6% sarcopenia), cIMT, aortic and carotid stiffness inversely correlated with muscle mass, strength and gait speed; cIMT remained independently associated with gait speed (β=-0.26) in multivariable analyses. Age and sex significantly modified the relationship between subclinical vasculopathy and muscle mass/function. Associations, only found in those aged ≥70, included cIMT with gait speed (β=-0.48) and knee strength (β=-9.33), and aortic augmentation index and aortic stiffness composite z-score with gait speed (β=-0.11 and β=-0.19 respectively). Among males, cIMT correlated with gait speed (β=-0.31). The association of subclinical vasculopathy with skeletal muscle mass and function in asymptomatic adults ≥55 years is best reflected by cIMT. The roles of mediating pathways deserve further evaluation.
Source Title: Aging
URI: https://scholarbank.nus.edu.sg/handle/10635/206553
ISSN: 19454589
DOI: 10.18632/aging.203142
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