Please use this identifier to cite or link to this item:
Title: Subclinical vasculopathy and skeletal muscle metrics in the singapore longitudinal ageing study
Authors: Lim, SL 
Liu, X
Gao, Q
Nyunt, SZ 
Gong, L 
Lunaria, JB 
Lam, CSP 
Richards, AM 
Wee, SL 
Ling, LH 
Ng, TP 
Keywords: aortic stiffness
carotid stiffness
endothelial function
muscle function
muscle mass
Linear Models
Longitudinal Studies
Middle Aged
Multivariate Analysis
Muscle, Skeletal
Vascular Diseases
Issue Date: 15-Jun-2021
Publisher: Impact Journals, LLC
Citation: Lim, SL, Liu, X, Gao, Q, Nyunt, SZ, Gong, L, Lunaria, JB, Lam, CSP, Richards, AM, Wee, SL, Ling, LH, Ng, TP (2021-06-15). Subclinical vasculopathy and skeletal muscle metrics in the singapore longitudinal ageing study. Aging 13 (11) : 14768-14784. ScholarBank@NUS Repository.
Abstract: Frailty is associated with future cardiovascular events in older adults. This cross-sectional study examined the relationship between subclinical vasculopathy with measures of skeletal muscle mass and function. Asymptomatic community-dwelling Asians ≥55 years underwent assessments for subclinical vasculopathy (carotid intima-media thickness (cIMT), aortic and carotid stiffness, and endothelial function), muscle mass (calf circumference adjusted for body mass index) and function (knee extension strength, 6-meter fast gait speed). Multivariable regression analyses for associates of muscle mass/function controlled for demographics and cardiometabolic risk factors. Among 336 participants (median age 62 years, 55.1% male, 3.6% sarcopenia), cIMT, aortic and carotid stiffness inversely correlated with muscle mass, strength and gait speed; cIMT remained independently associated with gait speed (β=-0.26) in multivariable analyses. Age and sex significantly modified the relationship between subclinical vasculopathy and muscle mass/function. Associations, only found in those aged ≥70, included cIMT with gait speed (β=-0.48) and knee strength (β=-9.33), and aortic augmentation index and aortic stiffness composite z-score with gait speed (β=-0.11 and β=-0.19 respectively). Among males, cIMT correlated with gait speed (β=-0.31). The association of subclinical vasculopathy with skeletal muscle mass and function in asymptomatic adults ≥55 years is best reflected by cIMT. The roles of mediating pathways deserve further evaluation.
Source Title: Aging
ISSN: 19454589
DOI: 10.18632/aging.203142
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Subclinical vasculopathy and skeletal muscle metrics in the singapore longitudinal ageing study.pdf761.14 kBAdobe PDF




checked on Aug 7, 2022

Page view(s)

checked on Aug 4, 2022


checked on Aug 4, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.