Please use this identifier to cite or link to this item: https://doi.org/10.1017/S0033291716001410
Title: Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study
Authors: Wang, C
Ji, F 
Hong, Z
Poh, JS
Krishnan, R 
Lee, J
Rekhi, G
Keefe, RSE 
Adcock, RA
Wood, SJ
Fornito, A
Pasternak, O
Chee, MWL 
Zhou, J
Keywords: Social Sciences
Science & Technology
Life Sciences & Biomedicine
Psychology, Clinical
Psychiatry
Psychology
At risk for psychosis
functional connectivity
LYRIKS
salience network
transition to psychosis
white-matter microstructure
EARLY-ONSET SCHIZOPHRENIA
CLINICAL HIGH-RISK
ULTRA-HIGH-RISK
1ST EPISODE SCHIZOPHRENIA
RESTING-STATE FMRI
DIFFUSION TENSOR
ALZHEIMERS-DISEASE
DEFAULT-MODE
FRONTOTEMPORAL DEMENTIA
SPATIAL STATISTICS
Issue Date: 1-Oct-2016
Publisher: CAMBRIDGE UNIV PRESS
Citation: Wang, C, Ji, F, Hong, Z, Poh, JS, Krishnan, R, Lee, J, Rekhi, G, Keefe, RSE, Adcock, RA, Wood, SJ, Fornito, A, Pasternak, O, Chee, MWL, Zhou, J (2016-10-01). Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study. PSYCHOLOGICAL MEDICINE 46 (13) : 2771-2783. ScholarBank@NUS Repository. https://doi.org/10.1017/S0033291716001410
Abstract: Background Salience network (SN) dysconnectivity has been hypothesized to contribute to schizophrenia. Nevertheless, little is known about the functional and structural dysconnectivity of SN in subjects at risk for psychosis. We hypothesized that SN functional and structural connectivity would be disrupted in subjects with At-Risk Mental State (ARMS) and would be associated with symptom severity and disease progression. Method We examined 87 ARMS and 37 healthy participants using both resting-state functional magnetic resonance imaging and diffusion tensor imaging. Group differences in SN functional and structural connectivity were examined using a seed-based approach and tract-based spatial statistics. Subject-level functional connectivity measures and diffusion indices of disrupted regions were correlated with CAARMS scores and compared between ARMS with and without transition to psychosis. Results ARMS subjects exhibited reduced functional connectivity between the left ventral anterior insula and other SN regions. Reduced fractional anisotropy (FA) and axial diffusivity were also found along white-matter tracts in close proximity to regions of disrupted functional connectivity, including frontal-striatal-thalamic circuits and the cingulum. FA measures extracted from these disrupted white-matter regions correlated with individual symptom severity in the ARMS group. Furthermore, functional connectivity between the bilateral insula and FA at the forceps minor were further reduced in subjects who transitioned to psychosis after 2 years. Conclusions Our findings support the insular dysconnectivity of the proximal SN hypothesis in the early stages of psychosis. Further developed, the combined structural and functional SN assays may inform the prognosis of persons at-risk for psychosis.
Source Title: PSYCHOLOGICAL MEDICINE
URI: https://scholarbank.nus.edu.sg/handle/10635/206098
ISSN: 00332917
14698978
DOI: 10.1017/S0033291716001410
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