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Title: Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men
Authors: Fu, Li
Yuen, Kevin CJ
Tint, Aye Nyein
Hoffman, Andrew R
Bongso, Ariff T 
Lee, Kok Onn 
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Insulin-like growth factors
Insulin-like growth factor binding proteins
Prostate-specific antigen
Male infertility
Seminal plasma
Sperm motility
Issue Date: 17-Jul-2021
Publisher: SPRINGER
Citation: Fu, Li, Yuen, Kevin CJ, Tint, Aye Nyein, Hoffman, Andrew R, Bongso, Ariff T, Lee, Kok Onn (2021-07-17). Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men. ENDOCRINE 74 (3). ScholarBank@NUS Repository.
Abstract: Purpose: Previous studies have suggested the involvement of serum insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the regulation of the female reproductive system. Little is known of these peptides in the seminal plasma (SP) of men and their potential effects on fertility. We assessed SP levels of these peptides in infertile men with low sperm motility (asthenozoospermic; AZ) and low sperm counts (oligozoospermic; OZ), its effects on in vivo sperm motility, and whether there is a correlation with aging. Methods: Twenty-eight infertile men (AZ; n = 18 and OZ; n = 10) and 20 fertile normozoospermic (NZ) men were studied. Seminal plasma IGF-I, IGF-II, IGFBP-2, IGFBP-3, and prostate-specific antigen (PSA) levels were measured, and spermatozoa mRNA transcript patterns were examined. Results: Asthenozoospermic men had higher SP IGF-I, IGF-II, IGFBP-2, and PSA levels than NZ and OZ men, whereas SP IGFBP-3 levels were similar between the three groups. Sperm count positively correlated with SP IGF-I, IGF-II, and IGFBP-2; sperm motility negatively correlated with SP IGF-II and IGFBP-2; and age correlated positively with SP IGF-II. The expression of IGF-I and IGF-II mRNA and mRNA receptors was detectable, but no variations in transcript levels were noted. Conclusion: Decreased sperm motility, but not sperm count, in infertile AZ men is associated with increased SP IGF-I, IGF-II, IGFBP-2, and PSA levels. Changes in SP IGFs and their interactions with IGFBPs and IGF receptors, and PSA levels suggest a role of these SP peptides in modulating sperm motility and possibly prostate disease development in aging men.
Source Title: ENDOCRINE
ISSN: 1355008X
DOI: 10.1007/s12020-021-02823-w
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