Please use this identifier to cite or link to this item: https://doi.org/10.1136/bjophthalmol-2014-305649
Title: Thyroid eye disease: a Southeast Asian experience
Authors: Lim, Nigel CS
Sundar, Gangadhara 
Amrith, Shantha
Lee, Kok Onn 
Keywords: Science & Technology
Life Sciences & Biomedicine
Ophthalmology
GRAVES OPHTHALMOPATHY
SELENIUM SUPPLEMENTATION
CLINICAL-FEATURES
RISK
ORBITOPATHY
SMOKING
AGE
Issue Date: 1-Apr-2015
Publisher: BMJ PUBLISHING GROUP
Citation: Lim, Nigel CS, Sundar, Gangadhara, Amrith, Shantha, Lee, Kok Onn (2015-04-01). Thyroid eye disease: a Southeast Asian experience. BRITISH JOURNAL OF OPHTHALMOLOGY 99 (4) : 512-518. ScholarBank@NUS Repository. https://doi.org/10.1136/bjophthalmol-2014-305649
Abstract: Aim To study the demographics, comorbidities, clinical manifestations and treatment methods of thyroid eye disease (TED) in Singapore. Methods In this retrospective case series, we analysed the case records of all patients with TED who presented at our multidisciplinary Thyroid Eye Clinic from November 2002 to October 2012. Results There were a total of 174 patients-111 female patients (63.8%) and 63 male patients (36.2%). The majority of the patients were ethnically Chinese (80.5%), followed by Malay (10.3%) and Indian (6.3%). The mean age was 40.2 years (SD±15.5, range 0.3-87.0). The commonest sign on ophthalmic examination was eyelid retraction (62.1%), followed by proptosis (61.0%) and lid lag (57.5). Acquired epiblepharon and corneal erosions were noted in 11.5% and 29.3% respectively. Eight patients (4.6%) had dysthyroid optic neuropathy. The mean exophthalmometry reading was 18.8 mm (SD±3.32, range 10.0-28.0). Mild, moderate and severe disease was noted in 71.3%, 20.7% and 8.0% respectively. Thyroid dysfunction was managed with anti-thyroid medication only (40.2%), ß blockers (19.5%), thyroxine replacement (14.4%), radioactive iodine (14.4%) and block-replace regime (9.8%). Clinically significant active orbitopathy was managed with intravenous corticosteroids (12.1%). Surgical procedures consisted of thyroidectomy (10.3%), eyelid surgery (8.6%), orbital decompression (7.5%), epiblepharon correction (2.3%) and strabismus surgery (0.6%). Conclusions Corneal erosion secondary to acquired epiblepharon is a common sign in East Asian patients with TED, thus increased awareness among physicians should be encouraged. Mean exophthalmometry values and frequencies of upper eyelid retraction and oedema are lower in East Asian patients compared with Caucasian patients. Among Singapore's multi-ethnic population, Malay patients with TED had the highest exophthalmometry reading.
Source Title: BRITISH JOURNAL OF OPHTHALMOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/205860
ISSN: 00071161
14682079
DOI: 10.1136/bjophthalmol-2014-305649
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