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Title: Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand
Authors: Wong, H.Y.
Prasad, A. 
Gan, S.U. 
Chua, J.J.E. 
Schwarz, H. 
Keywords: B cell
multiple sclerosis
Issue Date: 2020
Publisher: Frontiers Media S.A.
Citation: Wong, H.Y., Prasad, A., Gan, S.U., Chua, J.J.E., Schwarz, H. (2020). Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand. Frontiers in Immunology 11 : 571964. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The potent costimulatory effect of CD137 has been implicated in several murine autoimmune disease models. CD137 costimulates and polarizes antigen-specific T cells toward a potent Th1/Tc1 response, and is essential for the development of experimental autoimmune encephalomyelitis (EAE), a murine model of Multiple Sclerosis (MS). This study aimed to investigate a role of CD137 in MS. Immunohistochemical and immunofluorescence staining of MS brain tissues was used to identify expression of CD137. CD137+ cells were identified in MS brain samples, with active lesions having the highest frequency of CD137+ cells. CD137 expression was found on several leukocyte subsets, including T cells, B cells and endothelial cells. In particular, CD137+ B cells were found in meningeal infiltrates. In vitro experiments showed that CD137 engagement on activated B cells increased early TNF and persistent IL-6 secretion with increased cell proliferation. These CD137+ B cells could interact with CD137L-expressing cells, secrete pro-inflammatory cytokines and accumulate in the meningeal infiltrate. This study demonstrates CD137 expression by activated B cells, enhancement of the inflammatory activity of B cells upon CD137 engagement, and provides evidence for a pathogenic role of CD137+ B cells in MS. © Copyright © 2020 Wong, Prasad, Gan, Chua and Schwarz.
Source Title: Frontiers in Immunology
ISSN: 16643224
DOI: 10.3389/fimmu.2020.571964
Rights: Attribution 4.0 International
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