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https://doi.org/10.3390/cancers12123667
Title: | Common and unique transcription signatures of YAP and TAZ in gastric cancer cells | Authors: | Lee, Y. Finch-Edmondson, M. Cognart, H. Zhu, B. Song, H. Chuan, L.B. Sudol, M. |
Keywords: | Also known as WWTR1) Also known as YAP1 or YAP65) Cell-substrate junctions Gastric cancer Lipoprotein particles Platelet TAZ (transcriptional co-activator with PDZ-binding motif Transcriptome YAP (Yes-associated protein 1 |
Issue Date: | 2020 | Publisher: | MDPI AG | Citation: | Lee, Y., Finch-Edmondson, M., Cognart, H., Zhu, B., Song, H., Chuan, L.B., Sudol, M. (2020). Common and unique transcription signatures of YAP and TAZ in gastric cancer cells. Cancers 12 (12) : 1-15. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers12123667 | Rights: | Attribution 4.0 International | Abstract: | YAP and its paralog TAZ are the nuclear effectors of the Hippo tumour-suppressor pathway, and function as transcriptional co-activators to control gene expression in response to mechanical cues. To identify both common and unique transcriptional targets of YAP and TAZ in gastric cancer cells, we carried out RNA-sequencing analysis of overexpressed YAP or TAZ in the corresponding paralogous gene-knockouts (KOs), TAZ KO or YAP KO, respectively. Gene Ontology (GO) analysis of the YAP/TAZ-transcriptional targets revealed activation of genes involved in platelet biology and lipoprotein particle formation as targets that are common for both YAP and TAZ. However, the GO terms for cell-substrate junction were a unique function of YAP. Further, we found that YAP was indispensable for the gastric cancer cells to re-establish cell-substrate junctions on a rigid surface following prolonged culture on a soft substrate. Collectively, our study not only identifies common and unique transcriptional signatures of YAP and TAZ in gastric cancer cells but also reveals a dominant role for YAP over TAZ in the control of cell-substrate adhesion. @ 2020 by the authors. Licensee MDPI, Basel, Switzerland. | Source Title: | Cancers | URI: | https://scholarbank.nus.edu.sg/handle/10635/198985 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers12123667 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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