Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.placenta.2021.05.007
Title: Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study
Authors: Kaitu'u-Lino T.J.
Tong S.
Walker S.P.
MacDonald T.M.
Cannon P.
Nguyen T.-V.
Sadananthan S.A. 
Tint M.-T. 
Ong Y.Y.
Ling L.S. 
Gluckman P.D. 
Chong Y.-S. 
Godfrey K.M.
Chan S.-Y. 
Tan K.H. 
Lee Y.S. 
Michael N.
Eriksson J.G. 
Wlodek M.E. 
Keywords: Biomarker
Fetal growth restriction
SGA
SPINT1
Issue Date: Jul-2021
Publisher: W.B. Saunders Ltd
Citation: Kaitu'u-Lino T.J., Tong S., Walker S.P., MacDonald T.M., Cannon P., Nguyen T.-V., Sadananthan S.A., Tint M.-T., Ong Y.Y., Ling L.S., Gluckman P.D., Chong Y.-S., Godfrey K.M., Chan S.-Y., Tan K.H., Lee Y.S., Michael N., Eriksson J.G., Wlodek M.E. (2021-07). Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study. Placenta 110 : 24 - 28. ScholarBank@NUS Repository. https://doi.org/10.1016/j.placenta.2021.05.007
Abstract: Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks’ gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth. © 2021
Source Title: Placenta
URI: https://scholarbank.nus.edu.sg/handle/10635/192287
ISSN: 01434004
DOI: 10.1016/j.placenta.2021.05.007
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