1. ScholarBank@NUS
  2. 1. Staff
  3. Staff Publications
Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.placenta.2021.05.007
DC FieldValue
dc.titleMaternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study
dc.contributor.authorKaitu'u-Lino T.J.
dc.contributor.authorTong S.
dc.contributor.authorWalker S.P.
dc.contributor.authorMacDonald T.M.
dc.contributor.authorCannon P.
dc.contributor.authorNguyen T.-V.
dc.contributor.authorSadananthan S.A.
dc.contributor.authorTint M.-T.
dc.contributor.authorOng Y.Y.
dc.contributor.authorLing L.S.
dc.contributor.authorGluckman P.D.
dc.contributor.authorChong Y.-S.
dc.contributor.authorGodfrey K.M.
dc.contributor.authorChan S.-Y.
dc.contributor.authorTan K.H.
dc.contributor.authorLee Y.S.
dc.contributor.authorMichael N.
dc.contributor.authorEriksson J.G.
dc.contributor.authorWlodek M.E.
dc.date.accessioned2021-06-29T04:38:06Z
dc.date.available2021-06-29T04:38:06Z
dc.date.issued2021-07
dc.identifier.citationKaitu'u-Lino T.J., Tong S., Walker S.P., MacDonald T.M., Cannon P., Nguyen T.-V., Sadananthan S.A., Tint M.-T., Ong Y.Y., Ling L.S., Gluckman P.D., Chong Y.-S., Godfrey K.M., Chan S.-Y., Tan K.H., Lee Y.S., Michael N., Eriksson J.G., Wlodek M.E. (2021-07). Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study. Placenta 110 : 24 - 28. ScholarBank@NUS Repository. https://doi.org/10.1016/j.placenta.2021.05.007
dc.identifier.issn01434004
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/192287
dc.description.abstractFetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks’ gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth. © 2021
dc.language.isoen
dc.publisherW.B. Saunders Ltd
dc.sourceScopus
dc.subjectBiomarker
dc.subjectFetal growth restriction
dc.subjectSGA
dc.subjectSPINT1
dc.typeArticle
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPAEDIATRICS
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.placenta.2021.05.007
dc.description.sourcetitlePlacenta
dc.description.volume110
dc.description.page24 - 28
dc.description.codenPLACD
dc.published.statePublished
dc.grant.id17/63/154
dc.grant.idIS-BRC-1215-20004
dc.grant.idMC_UU_12011/4
dc.grant.idNF–SI-0515-10042
dc.grant.idRG/15/17/3174
dc.grant.id598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP
dc.grant.id1065854
dc.grant.id1136418
dc.grant.id1159261
dc.grant.id116071
dc.grant.id1183854
dc.grant.idPCT/AU2019/050,516
dc.grant.idNMRC /TCR/004- NUS /2008
dc.grant.idNMRC /TCR/012- NUHS /2014
dc.grant.fundingagencyMedical Research Council, MRC
dc.grant.fundingagencyNational Institute for Health Research, NIHR
dc.grant.fundingagencyBritish Heart Foundation, BHF
dc.grant.fundingagencyEuropean Commission
dc.grant.fundingagencyNational Health and Medical Research Council, NHMRC
dc.grant.fundingagencyAgency for Science, Technology and Research, A*STAR
dc.grant.fundingagencyNational Medical Research Council, NMRC
dc.grant.fundingagencyMinistry of Health -Singapore, MOH
dc.grant.fundingagencySingapore Institute for Clinical Sciences, SICS
dc.grant.fundingagencyNational Research Foundation Singapore, NRF
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
(276)_postprint_Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks....pdf625.98 kBAdobe PDF

OPEN

Post-printView/Download
(276)_postprint_Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks... (Figures).pdf186.38 kBAdobe PDF

OPEN

Post-printView/Download

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.