Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/191362
Title: Epigenetic plasticity and redox regulation of neural stem cell state and fate
Authors: EMMY TAY XUE YUN 
CHIA KIMBERLY 
ONG SEK TONG, DERRICK 
Keywords: Ageing
Alzheimer's disease
Epigenetics
Metabolism
Neural stem cells
Reactive oxygen species
Redox
Issue Date: 6-Mar-2021
Publisher: Elsevier BV
Citation: EMMY TAY XUE YUN, CHIA KIMBERLY, ONG SEK TONG, DERRICK (2021-03-06). Epigenetic plasticity and redox regulation of neural stem cell state and fate. Free Radical Biology and Medicine. ScholarBank@NUS Repository.
Abstract: The neural stem cells (NSCs) are essential for normal brain development and homeostasis. The cell state (i.e. quiescent versus activated) and fate (i.e. the cell lineage of choice upon differentiation) of NSCs are tightly controlled by various redox and epigenetic regulatory mechanisms. There is an increasing appreciation that redox and epigenetic regulations are intimately linked, but how this redox-epigenetics crosstalk affects NSC activity remains poorly understood. Another unresolved topic is whether the NSCs actually contribute to brain ageing and neurodegenerative diseases. In this review, we aim to 1) distill concepts that underlie redox and epigenetic regulation of NSC state and fate; 2) provide examples of the redox-epigenetics crosstalk in NSC biology; and 3) highlight potential redox- and epigenetic-based therapeutic opportunities to rescue NSC dysfunctions in ageing and neurodegenerative diseases.
Source Title: Free Radical Biology and Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/191362
ISSN: 0891-5849
1873-4596
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